Purine acyclic nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted- ethoxy)methyl]purines as candidate antivirals

Abstract

Several acyclic puromycin analogues containing hydrocarbon substituents on the 1'-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.