Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Aug;37(4):723-9.

Human platelet arylsulphatases: identification and capacity to destroy SRS-A

D D Metcalfe, L M Corash, M Kaliner

Human platelet arylsulphatases: identification and capacity to destroy SRS-A

D D Metcalfe et al. Immunology. 1979 Aug.

Abstract

Arylsulphatases IIA and IIB have been separately identified in human platelets by use of anion exchange chromatography and gel filtration. Arylsulphatase IIA had a molecular weight of 160,000 and a pH optimum of 4.5. Arylsulphatase IIB had a molecular weight of 60,000 and a pH optimum of 5.5. Both arylsulphatases IIA and IIB were inhibited by phosphate and sulphate ions characteristic of this enzyme class. Platelets, upon exposure to ionophore A-23187 or thrombin, discharged arylsulphatase coincident with beta-glcuronidase release. Partially purified platelet arylsulphatase IIB inactivated rat SRS-A.

PubMed Disclaimer

References

    1. Histochemistry. 1975 Sep 29;44(4):307-12 - PubMed
    1. J Clin Invest. 1975 Dec;56(6):1635-49 - PubMed
    1. Adv Enzymol Relat Subj Biochem. 1960;22:205-35 - PubMed
    1. J Physiol. 1960 Jun;151:416-35 - PubMed
    1. J Immunol. 1977 May;118(5):1569-73 - PubMed

LinkOut - more resources