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. 2025 Aug 26;3(5):e70041.
doi: 10.1002/cesm.70041. eCollection 2025 Sep.

Meta-Analysis Using Time-to-Event Data: A Tutorial

Ashma Krishan  1 , Kerry Dwan  2
Affiliations

Meta-Analysis Using Time-to-Event Data: A Tutorial

Ashma Krishan et al. Cochrane Evid Synth Methods. .

Abstract

This tutorial focuses on trials that assess time-to-event outcomes. We explain what hazard ratios are, how to interpret them and demonstrate how to include time-to-event data in a meta-analysis. Examples are presented to help with understanding. Accompanying the tutorial is a micro learning module, where we demonstrate a few approaches and give you the chance to practice calculating the hazard ratio. Time-to-event micro learning module https://links.cochrane.org/cesm/tutorials/time-to-event-data.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Published Kaplan‐Meier curve.
See this image and copyright information in PMC

References

    1. Langer P., John L., Monsef I., et al., “Daratumumab and Antineoplastic Therapy Versus Antineoplastic Therapy Only for Adults With Newly Diagnosed Multiple Myeloma Ineligible for Transplant,” Cochrane Database of Systematic Reviews 5, no. 5 (2024): CD013595, 10.1002/14651858.CD013595.pub2. - DOI - PMC - PubMed
    1. Collett D., Modelling Survival Data in Medical Research (A Chapman & Hall Book, 2015). Third Edition.
    1. Keech A., Gebski V., and Pike R., Interpreting and Reporting Clinical Trials. A Guide to the Consort Statement and Principles of Randomised Controlled Trials (Australasian Medical Publishing Company, 2007).
    1. Cox D. R., “Regression Models and Life‐Tables,” Journal of the Royal Statistical Society Series B: Statistical Methodology 34, no. 2 (1972): 187–202, 10.1111/j.2517-6161.1972.tb00899.x. - DOI
    1. Review Manager (RevMan) , Version 8.1.1. The Cochrane Collaboration, 2024.

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