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Editorial
. 2025 Aug 12:13:1653034.
doi: 10.3389/fcell.2025.1653034. eCollection 2025.

Editorial: Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis, volume II

Yong Qiu  1   2 , Xiao Xiao Tang  3   4 , Shigeyuki Shichino  5 , Prem Prakash Kushwaha  6 , Yan Y Sanders  7 , Remo Castro Russo  8 , Chunheng Mo  1
Affiliations
Editorial

Editorial: Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis, volume II

Yong Qiu et al. Front Cell Dev Biol. .
No abstract available

Keywords: asthma; bronchopulmonary dysplasia; chronic obstructive pulmonary disease; lung fibrosis; lung regeneration.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

FIGURE 1
FIGURE 1
Stem cell populations involved in lung regeneration and repair after injury. After airway damage, basal cells have the capacity to differentiate into both club cells and ciliated cells. Club cells, in turn, can give rise to ciliated cells and are capable of dedifferentiating into basal cells when basal cells are lost. BASCs contribute to the regeneration of both club cells and ciliated cells. In response to alveolar injury, Club cells and BASCs play a key role in replenishing AT2 cells. LNEPs are able to differentiate into AT2 cells, while RASCs primarily give rise to AT2 cells. Additionally, AT2 cells have the ability to differentiate into AT1 cells. Extracellular matrix, ECM; Type 1 alveolar epithelial cells, AT1; Type 2 alveolar epithelial cells, AT2; Alveolar macrophages, AM; Smooth muscle cell, SMC; Lineage-negative epithelial progenitors, LNEPs; Bronchioalveolar stem cells, BASCs; Respiratory airway secretory cells, RASCs.
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