Immunochemical cross-reactions between type III group B Streptococcus and type 14 Streptococcus pneumoniae
- PMID: 40876
- PMCID: PMC414541
- DOI: 10.1128/iai.25.3.960-963.1979
Immunochemical cross-reactions between type III group B Streptococcus and type 14 Streptococcus pneumoniae
Abstract
Serological cross-reactions between certain streptococci and some serotypes of Streptococcus pneumoniae have been reported. These studies detail the serological cross-reactivity observed between hot HCl-extracted group b streptococcus type III (GBS III) antigens and S. pneumoniae type 14 (Pn 14) polysaccharide. Similar electrophoretic migration patterns of GBS III and Pn 14 were observed when either type-specific BGS III antisera or pneumococcal omniserum was utilized to precipitate these antigens. Both the GBS III antigen and the Pn 14 polysaccharide migrated toward the cathode, whereas all other pneumococcal polysaccharides migrated toward the anode. No cross-reactions were observed between GBS III antisera and the 11 other types of pneumococcal polysaccharides. Lines of identity were observed between type-specific GBS III antisera and monospecific Pn 14 antiserum with either GBS III antigens or purified Pn 14 polysaccharide. The cross-reacting antigens of GBS III and Pn 14 appear to be identical by immunodiffusion and immunoelectrophoresis.
Similar articles
-
Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14.Infect Immun. 2002 Apr;70(4):1724-38. doi: 10.1128/IAI.70.4.1724-1738.2002. Infect Immun. 2002. PMID: 11895934 Free PMC article.
-
Cross-reactions between pneumococci and other streptococci due to C polysaccharide and F antigen.J Clin Microbiol. 1987 Oct;25(10):1854-9. doi: 10.1128/jcm.25.10.1854-1859.1987. J Clin Microbiol. 1987. PMID: 3499450 Free PMC article.
-
Structurally identical capsular polysaccharide expressed by intact group B streptococcus versus Streptococcus pneumoniae elicits distinct murine polysaccharide-specific IgG responses in vivo.J Immunol. 2012 Jun 1;188(11):5238-46. doi: 10.4049/jimmunol.1200132. Epub 2012 Apr 20. J Immunol. 2012. PMID: 22523389 Free PMC article.
-
Immunochemical characterization of the polysaccharide antigens of group B streptococci.Rev Infect Dis. 1988 Jul-Aug;10 Suppl 2:S367-71. doi: 10.1093/cid/10.supplement_2.s367. Rev Infect Dis. 1988. PMID: 3142018 Review.
-
Survey of immunological features of the alpha-like proteins of Streptococcus agalactiae.Clin Vaccine Immunol. 2015 Feb;22(2):153-9. doi: 10.1128/CVI.00643-14. Epub 2014 Dec 24. Clin Vaccine Immunol. 2015. PMID: 25540270 Free PMC article. Review.
Cited by
-
Age-stratified prevalences of pneumococcal-serotype-specific immunoglobulin G in England and their relationship to the serotype-specific incidence of invasive pneumococcal disease prior to the introduction of the pneumococcal 7-valent conjugate vaccine.Clin Vaccine Immunol. 2007 Nov;14(11):1442-50. doi: 10.1128/CVI.00264-07. Epub 2007 Sep 19. Clin Vaccine Immunol. 2007. PMID: 17881503 Free PMC article.
-
Development of an Extended-Specificity Multiplex Immunoassay for Detection of Streptococcus pneumoniae Serotype-Specific Antigen in Urine by Use of Human Monoclonal Antibodies.Clin Vaccine Immunol. 2017 Dec 5;24(12):e00262-17. doi: 10.1128/CVI.00262-17. Print 2017 Dec. Clin Vaccine Immunol. 2017. PMID: 28978509 Free PMC article.
-
Conformation and Cross-Protection in Group B Streptococcus Serotype III and Streptococcus pneumoniae Serotype 14: A Molecular Modeling Study.Pharmaceuticals (Basel). 2019 Feb 13;12(1):28. doi: 10.3390/ph12010028. Pharmaceuticals (Basel). 2019. PMID: 30781826 Free PMC article.
-
Streptococcus pneumoniae serotype 1 burden in the African meningitis belt: exploration of functionality in specific antibodies.Clin Vaccine Immunol. 2015 Apr;22(4):404-12. doi: 10.1128/CVI.00758-14. Epub 2015 Feb 4. Clin Vaccine Immunol. 2015. PMID: 25651921 Free PMC article.
-
The immune response to group B streptococcus type III capsular polysaccharide is directed to the -Glc-GlcNAc-Gal- backbone epitope.Glycoconj J. 2011 Dec;28(8-9):557-62. doi: 10.1007/s10719-011-9354-1. Epub 2011 Oct 8. Glycoconj J. 2011. PMID: 21984010
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources