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. 2025 Aug 29;8(8):CD016207.
doi: 10.1002/14651858.CD016207.

Pharmacological antiemetic prophylaxis and treatment for opioid-induced nausea and vomiting (OINV) in patients treated for cancer pain and cancer-related breathlessness

Jan Gaertner  1   2 , Christian Appenzeller-Herzog  3 , Vanessa Piechotta  4 , Guido Schwarzer  5 , Constanze Rémi  6 , Katja Suter  1 , Christopher Boehlke  1   2
Affiliations

Pharmacological antiemetic prophylaxis and treatment for opioid-induced nausea and vomiting (OINV) in patients treated for cancer pain and cancer-related breathlessness

Jan Gaertner et al. Cochrane Database Syst Rev. .

Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of pharmacological treatments given prophylactically or on-demand after onset of opioid-induced nausea and vomiting (OINV) in people being treated for cancer pain or cancer dyspnoea, when compared to placebo or other pharmacological interventions.

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Conflict of interest statement

  1. JG: no commercial or non‐commercial conflicts of interest relevant to this review. He is a specialist palliative care physician and manages palliative care patients.

  2. CAH: no commercial or non‐commercial conflicts of interest relevant to this review. He works as a medical information specialist.

  3. VP: no commercial or non‐commercial conflicts of interest relevant to this review.

  4. GS: received personal consulting fees for 'External statistical consultant of Roche Pharma AG, Grenzach‐Wyhlen, Germany'

  5. CR: no commercial or non‐commercial conflicts of interest relevant to this review. She is a pharmacist leading the Competence Centre for Palliative Pharmacy.

  6. KS: no commercial or non‐commercial conflicts of interest relevant to this review. She is a pharmacist and project manager.

  7. CB: planned an investigator‐initiated study that is potentially eligible for inclusion [52]. Therefore, he will not make study eligibility decisions about this study; if it is included, he will not extract data from it, carry out the risk of bias assessment, or perform GRADE assessments for comparisons and outcomes that include this study (section 5.6 of Cochrane’s Conflict of Interest Policy). CB is a specialist palliative care physician and manages palliative care patients.

References

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    1. Laugsand EA, Kaasa S, Klepstad P. Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations. Palliative Medicine 2011;25(5):442-53. [DOI: 10.1177/0269216311404273] - DOI - PubMed
    1. Sande TA, Laird BJA, Fallon MT. The management of opioid-induced nausea and vomiting in patients with cancer: a systematic review. Journal of Palliative Medicine 2019;22(1):90-7. [DOI: 10.1089/jpm.2018.0260] - DOI - PubMed

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