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Review
. 2025:1478:51-60.
doi: 10.1007/978-3-031-88361-3_3.

Mitochondrial Quality Control

Yuntian Guan  1   2 , Zhen Yan  3   4   5
Affiliations
Review

Mitochondrial Quality Control

Yuntian Guan et al. Adv Exp Med Biol. 2025.

Abstract

Mitochondria, the power plants of cells, are essential for various cellular functions. In skeletal muscle, mitochondria form a network, called mitochondrial reticulum, which fuels muscle contractile and metabolic functions. The high degree of structure-to-function specialization of mitochondria in skeletal muscle implies that it is closely gauged and regulated to maintain energy production capacity to match the functional demands. The processes that regulate the overall structure and function of mitochondrial reticulum are collectively referred to as mitochondrial quality control. Mitochondrial quality control consists of mitochondrial biogenesis, dynamics (i.e., fission and fusion), and selective degradation via proteolysis and mitophagy. In this chapter, we will discuss different aspects of contemporary understanding of mitochondrial quality control, their respective mechanisms, and their adaptability to exercise training.

Keywords: Adaptation; Exercise; Mitochondrial biogenesis; Mitochondrial fission; Mitochondrial fusion; Mitochondrial reticulum; Mitophagy; Skeletal muscle.

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References

    1. Ashford TP, Porter KR (1962) Cytoplasmic components in hepatic cell lysosomes. J Cell Biol 12:198–202 - PubMed - PMC
    1. Benard G, Faustin B et al (2006) Physiological diversity of mitochondrial oxidative phosphorylation. Am J Physiol Cell Physiol 291(6):C1172–C1182. https://doi.org/10.1152/ajpcell.00195.2006 - DOI - PubMed
    1. Caffin F, Prola A et al (2013) Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice. J Physiol 591(23):6017–6037. https://doi.org/10.1113/jphysiol.2013.263079 - DOI - PubMed - PMC
    1. Chen H, Chomyn A, Chan DC (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280(28):26185–26192. https://doi.org/10.1074/jbc.M503062200 - DOI - PubMed
    1. Doerrier C, Garcia-Souza LF et al (2018) High-resolution FluoRespirometry and OXPHOS protocols for human cells, Permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31–70. https://doi.org/10.1007/978-1-4939-7831-1_3 - DOI - PubMed

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