Early-onset systemic lupus erythematosus-ANCA-associated vasculitis overlap syndrome caused by DNASE1L3 deficiency

Clément Triaille^{1

2}, Sohei Makita³, Kévin Côté⁴, Geneviève Benoit⁵, Philippe M Campeau⁶, Jean Jacques De Bruycker¹, Ai Ra³, Jon J McCord⁷, Khampoun Sayasith⁸, R Bryan Sutton^{7

9}, Fabien Touzot^{8

10}, Elie Haddad^{8

10}, Boris Reizis³, Marie-Paule Morin¹

Affiliations

¹ Pediatric rheumatology and immunology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada.
² Pôle de pathologies rhumatismales systémiques et inflammatoires (RUMA), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.
³ Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
⁴ Pathology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
⁵ Pediatric Nephrology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada.
⁶ Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
⁷ Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
⁸ Centre de recherche Azrieli, Montreal, QC, Canada.
⁹ Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
¹⁰ Department of Pediatrics, Department of microbiology, immunology and infectious diseases, CHU Sainte-Justine Azrieli Research Center, Université de Montréal, Montreal, QC, Canada.

Clément Triaille et al. Rheumatology (Oxford). 2025.

. 2025 Aug 29:keaf459.

doi: 10.1093/rheumatology/keaf459. Online ahead of print.

¹ Pediatric rheumatology and immunology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada.
² Pôle de pathologies rhumatismales systémiques et inflammatoires (RUMA), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.
³ Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
⁴ Pathology Division, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada.
⁵ Pediatric Nephrology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada.
⁶ Division of Medical Genetics, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.
⁷ Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
⁸ Centre de recherche Azrieli, Montreal, QC, Canada.
⁹ Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
¹⁰ Department of Pediatrics, Department of microbiology, immunology and infectious diseases, CHU Sainte-Justine Azrieli Research Center, Université de Montréal, Montreal, QC, Canada.

No abstract available

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