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. 2025 Aug 13:38:14237.
doi: 10.3389/ti.2025.14237. eCollection 2025.

Updates on Donor-Derived Infection in Solid Organ Transplantation, Report from the 2024 GTI (Infection and Transplantation Group) Annual Meeting

Carole Eldin  1 , Paolo Antonio Grossi  2 , Victoria Manda  3 , Nassim Kamar  4 , Olivier Lortholary  5 , Hans H Hirsch  6 , Jean-Ralph Zahar  7 , Vincent Michel Borderie  8 , François Parquin  9 , Eric Epailly  10 , Florence Ader  11 , Emmanuel Morelon  12 , Edouard Forcade  13 , David Lebeaux  14 , Jérôme Dumortier  15 , Filomena Conti  16 , Agnes Lefort  17   18 , Anne Scemla  19 , Hannah Kaminski  20
Affiliations

Updates on Donor-Derived Infection in Solid Organ Transplantation, Report from the 2024 GTI (Infection and Transplantation Group) Annual Meeting

Carole Eldin et al. Transpl Int. .

Abstract

The annual meeting of the French GTI (Transplantation and Infection Group) focused on donor-derived infections (DDIs) in solid organ transplant (SOT) recipients. Given the ongoing organ shortage, rigorous donor screening is essential to detect potential infectious risks. Donor evaluation should include medical history, travel, vaccination status, serologies, and exposures. Various pathogens are of concern, including viruses (HIV, hepatitis, BK polyomavirus), multidrug-resistant bacteria, fungi, and emerging arboviruses like West Nile virus and dengue. HIV-positive donor to HIV-positive recipient (D+/R+) transplantations are increasingly accepted, with promising outcomes. Hepatitis E (HEV) is now the most common viral hepatitis and may lead to chronic infection in SOT recipients, requiring ribavirin treatment. Non-Candida fungal infections, though rare, are associated with high mortality and demand early recognition. Climate change and globalization are expanding the range of vector-borne infections, necessitating seasonal and regional screening. BK polyomavirus remains a major complication in kidney transplant recipients, and monitoring viral load is critical. Bacterial infections from donors are uncommon but should be evaluated based on site, organism, resistance profile, and treatment history. Overall, maintaining safety in transplantation requires constant vigilance, updated knowledge, and personalized risk-benefit analysis to adapt to emerging infectious threats-especially amid ongoing organ scarcity.

Keywords: Bk virus; HIV; chronic hepatitis; donor-derived infection; non-candida derived fungal infection.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Recommendations in France for cases where HEV RNA is detected in the recipient’s blood following transplantation from a HEV-positive deceased organ donor.
FIGURE 2
FIGURE 2
Distribution of proven/probable donor derived non-candida fungal infections, absolute count (percent).
FIGURE 3
FIGURE 3
Biomedecine National Agency algorithm, donor screening for West Nile Virus.
See this image and copyright information in PMC

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