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Case Reports
. 2025 Sep 26;13(27):107158.
doi: 10.12998/wjcc.v13.i27.107158.

Primary signet ring cell carcinoma of the female urethra: A case report

Pan Xu  1   2 , Shan-Shan Ling  1 , E Hu  1 , Bi-Xia Yi  1
Affiliations
Case Reports

Primary signet ring cell carcinoma of the female urethra: A case report

Pan Xu et al. World J Clin Cases. .

Abstract

Background: Primary signet ring cell carcinoma of the urethra in women is an exceedingly rare malignancy. It was first reported in postmenopausal women in 1987, and only five patients have been reported to date.

Case summary: A 61-year-old woman presented with irregular vaginal bleeding, and subsequent evaluation identified a tumor located in the distal urethra. Upon diagnosis of primary urethral carcinoma, she underwent a distal urethrectomy. Histopathological analysis demonstrated that the tumor consisted of a combination of intestinal adenocarcinoma and signet ring cell carcinoma. At the 12-month postoperative follow-up, there was no evidence of disease recurrence.

Conclusion: This case report highlights the exceptional rarity of female urethral signet ring cell carcinoma, emphasizing the importance of early clinical detection and the necessity for precise and conservative surgical intervention.

Keywords: Case report; Female urethra; Signet ring cell carcinoma; Urethral mass; Vaginal mass.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare that they have no conflicts of interest in relation to this case report.

Figures

Figure 1
Figure 1
Gross specimen of the complete urethral tumor tissue which is approximately 2 cm in diameter.
Figure 2
Figure 2
Hematoxylin and Eosin staining. Original magnification of 200 ×.
See this image and copyright information in PMC

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