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Published Erratum
. 2025 Aug 29;15(1):31847.
doi: 10.1038/s41598-025-16464-w.

Author Correction: Bone marrow-derived mesenchymal stem cells (BMSCs) repair acute necrotized pancreatitis by secreting microRNA-9 to target the NF-κB1/p50 gene in rats

Daohai Qian #  1   2   3 , Ge Wei #  2 , Chenglei Xu #  2 , Zhigang He  2 , Jie Hua  2 , Jian Li  2 , Qili Hu  2 , Shengping Lin  4 , Jian Gong  2 , Hongbo Meng  2 , Bo Zhou  2 , Hongfei Teng  2 , Zhenshun Song  5
Affiliations
Published Erratum

Author Correction: Bone marrow-derived mesenchymal stem cells (BMSCs) repair acute necrotized pancreatitis by secreting microRNA-9 to target the NF-κB1/p50 gene in rats

Daohai Qian et al. Sci Rep. .
No abstract available

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Figures

Fig. 3
Fig. 3
pri-miR-9-BMSCs could inhibit the local inflammatory response. The expressions of pro-inflammatory cytokines(IL-1β, IL-6, TNF-α, and MPO), NF-κB proteins (p-P65, P50) and CD68 were significantly decreased by pir-miR-9-BMSCs. On the contrary, the expressions of superoxide dismutase (SOD1 and SOD2) and anti-inflammatory proteins (IκBα and IκBβ) were significantly increased by pir-miR-9-BMSCs, compared with SAP, SAP + PBS, BMSCs, or TuD-BMSCs groups by gPCR (A,B), Western-blot (C,D) and IHC (E,F). Data are shown as mean ± SD for at least 3 separate experiments. %%P < 0.01, compared with NC, #p < 0.05, ##p < 0.01 and ###p < 0.001, compared with NC, +p < 0.05, ++p < 0.01 and +++p < 0.001, compared with SAP, *p < 0.05 and **p < 0.01, compared with SAP + PBS, @p < 0.05 and @@p < 0.01, compared with BMSCs, $p < 0.05 and $$p < 0.01, compared with Empty-virus BMSCs, †p < 0.05, ††p < 0.01 and †††p < 0.001, compared with TuD-BMSCs by using paired t test. gPCR, General PCR, IHC, immunohistochemistry.
Fig. 4
Fig. 4
miR-9 could antagonize the local inflammatory response. The expressions of IL-1β, IL-6, TNF-α, MPO, p-P65, P50, and CD68 were significantly decreased by miR-9a-5p agomir. Inversely, the expressions of SOD1, SOD2, IκBα, and IκBβ were significantly increased by miR-9a-5p agomir, compared with SAP + PBS or miR-9a-5p control group, by gPCR (A,B), Western-blot (C,D) and IHC (E,F). Data are shown as mean ± SD for at least 3 separate experiments. %P < 0.05, compared with NC, #p < 0.05 and ###p < 0.001, compared with NC, *p < 0.05, **p < 0.01 and ***p < 0.001, compared with SAP + PBS, &p < 0.05, &&p < 0.01, and &&&p < 0.001, compared with miR-9a-5p control by using paired t test. SOD, Superoxide Dismutase, gPCR, General PCR, IHC, immunohistochemistry.
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