Covalent chemical probes

Keriann M Backus^{1

2

3

4

5

6}, Andrew J Wilson⁷

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
² Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
³ Molecular Biology Institute, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁴ DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁵ Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁶ Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁷ School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK. a.j.wilson.1@bham.ac.uk.

PMID: 40883564
PMCID: PMC12397361
DOI: 10.1038/s42004-025-01652-6

Editorial

Covalent chemical probes

Keriann M Backus et al. Commun Chem. 2025.

. 2025 Aug 29;8(1):266.

doi: 10.1038/s42004-025-01652-6.

Authors

Keriann M Backus^{1

2

3

4

5

6}, Andrew J Wilson⁷

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
² Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
³ Molecular Biology Institute, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁴ DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁵ Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁶ Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA. kbackus@mednet.ucla.edu.
⁷ School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK. a.j.wilson.1@bham.ac.uk.

PMID: 40883564
PMCID: PMC12397361
DOI: 10.1038/s42004-025-01652-6

Abstract

Communications Chemistry is pleased to introduce a Collection of research works focused on recent developments within the interdisciplinary field of Covalent chemical probes. Here, the Guest Editors highlight key themes and look towards the future of this research field.

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References

1. Morese, P. A. et al. Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding. Commun. Chem.8, 111 (2025). - PMC - PubMed
1. Chen, X. et al. Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun. Chem.5, 36 (2022). - PMC - PubMed
1. Lee, J., Son, S., Lee, M. & Park, S. B. Development of potential immunomodulatory ligands targeting natural killer T cells inspired by gut symbiont-derived glycolipids. Commun. Chem.8, 98 (2025). - PMC - PubMed
1. Maspero, E. et al. Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4. Commun. Chem.8, 164 (2025). - PMC - PubMed
1. Cai, G. et al. Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells. Commun. Chem.7, 144 (2024). - PMC - PubMed

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Covalent chemical probes

Affiliations

Covalent chemical probes

Authors

Affiliations

Abstract

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