Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Aug 29.
doi: 10.1111/nph.70524. Online ahead of print.

Guanylate-binding proteins: emerging critical functions in plant development, immunity and stress response

Lucie Fernandez-Lochu  1 , Martine Lemaire-Chamley  1 , Christian Chevalier  1
Affiliations
Review

Guanylate-binding proteins: emerging critical functions in plant development, immunity and stress response

Lucie Fernandez-Lochu et al. New Phytol. .

Abstract

Guanylate-binding proteins (GBPs) are large GTPases that belong to the Dynamin Superfamily Protein family. In humans, GBPs are well-characterized interferon-induced GTPases, playing a central role in cell-autonomous innate immunity against infections, inflammation and cancer. GBPs orthologs have been identified in plants only recently. Despite the limited number of reports describing their functional characterization, plant GBPs share common structural and biological features, as well as functions, with animal GBPs. This review aimed at highlighting the recent knowledge acquired on the critical role of GBPs and the associated mechanisms in plant developmental processes and in plant immunity to biotic aggressions through the control of gene expression.

Keywords: Dynamin Superfamily Protein; biomolecular condensates; guanylate‐binding protein; innate immunity; large GTPase; plant development; stress.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Britzen‐Laurent N, Bauer M, Berton V, Fischer N, Syguda A, Reipschläger S, Naschberger E, Herrmann C, Stürzl M. 2010. Intracellular trafficking of guanylate‐binding proteins is regulated by heterodimerization in a hierarchical manner. PLoS ONE 5: e14246.
    1. Cao Y, Yan H, Sheng M, Liu Y, Yu X, Li Z, Xu W, Su Z. 2024. Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome. BMC Biology 22: 80.
    1. Castroverde CDM, Dina D. 2021. Temperature regulation of plant hormone signaling during stress and development. Journal of Experimental Botany 72: 7436–7458.
    1. Cheng YS, Colonno RJ, Yin FH. 1983. Interferon induction of fibroblast proteins with guanylate binding activity. Journal of Biological Chemistry 258: 7746–7750.
    1. Ghosh A, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C. 2006. How guanylate‐binding proteins achieve assembly‐stimulated processive cleavage of GTP to GMP. Nature 440: 101–104.

LinkOut - more resources