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Review
. 2025 Aug 29.
doi: 10.1111/nph.70524. Online ahead of print.

Guanylate-binding proteins: emerging critical functions in plant development, immunity and stress response

Lucie Fernandez-Lochu  1 , Martine Lemaire-Chamley  1 , Christian Chevalier  1
Affiliations
Review

Guanylate-binding proteins: emerging critical functions in plant development, immunity and stress response

Lucie Fernandez-Lochu et al. New Phytol. .

Abstract

Guanylate-binding proteins (GBPs) are large GTPases that belong to the Dynamin Superfamily Protein family. In humans, GBPs are well-characterized interferon-induced GTPases, playing a central role in cell-autonomous innate immunity against infections, inflammation and cancer. GBPs orthologs have been identified in plants only recently. Despite the limited number of reports describing their functional characterization, plant GBPs share common structural and biological features, as well as functions, with animal GBPs. This review aimed at highlighting the recent knowledge acquired on the critical role of GBPs and the associated mechanisms in plant developmental processes and in plant immunity to biotic aggressions through the control of gene expression.

Keywords: Dynamin Superfamily Protein; biomolecular condensates; guanylate‐binding protein; innate immunity; large GTPase; plant development; stress.

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