"Epitope-based matching for platelet transfusion overview: Is it time?"-Insights and future directions from the 2024 American Red Cross symposium on platelet component selection

Affiliations

¹ American Red Cross, Northeast Division, UMass Chan Medical School, Dedham, Massachusetts, USA.
² University of Washington/Fred Hutch Cancer Center, Seattle, Washington, USA.
³ Histocompatibility and Immunogenetics, Colindale, UK.
⁴ NHS Blood and Transplant, Bristol, UK.
⁵ Hospital Israelita Albert Einstein, São Paulo, Brazil.
⁶ Section of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
⁷ NYU Langone Health, Transplant Institute, New York, New York, USA.
⁸ CIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, Minnesota, USA.
⁹ American Red Cross, Penn-Jersey-Carolina Division, Philadelphia, Pennsylvania, USA.

PMID: 40884418
DOI: 10.1111/trf.18392

Review

"Epitope-based matching for platelet transfusion overview: Is it time?"-Insights and future directions from the 2024 American Red Cross symposium on platelet component selection

Neng Yu et al. Transfusion. 2025.

. 2025 Aug 30.

doi: 10.1111/trf.18392. Online ahead of print.

Authors

Affiliations

¹ American Red Cross, Northeast Division, UMass Chan Medical School, Dedham, Massachusetts, USA.
² University of Washington/Fred Hutch Cancer Center, Seattle, Washington, USA.
³ Histocompatibility and Immunogenetics, Colindale, UK.
⁴ NHS Blood and Transplant, Bristol, UK.
⁵ Hospital Israelita Albert Einstein, São Paulo, Brazil.
⁶ Section of Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
⁷ NYU Langone Health, Transplant Institute, New York, New York, USA.
⁸ CIBMTR (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, Minnesota, USA.
⁹ American Red Cross, Penn-Jersey-Carolina Division, Philadelphia, Pennsylvania, USA.

PMID: 40884418
DOI: 10.1111/trf.18392

No abstract available

Keywords: cumulative DSA‐MFI based platelet selections; functional epitope (Eplet)‐based matching; molecular compatibility; multifunctional donor registries.

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References

REFERENCES

1. Duquesnoy RJ, Filip DJ, Rodey GE, Rimm AA, Aster RH. Successful transfusion of platelets “mismatched” for HLA antigens to alloimmunized thrombocytopenic patients. Am J Hematol. 1977;2(3):219–226.
1. Duquesnoy RJ. Reflections on HLA epitope‐based matching for transplantation. Front Immunol. 2016;7:469.
1. Cohn CS. Platelet transfusion refractoriness: how do I diagnose and manage? Hematology Am Soc Hematol Educ Program. 2020;2020(1):527–532.
1. McFarland JG, Anderson AJ, Slichter SJ. HLA‐alloimmunization as a cause of platelet refractoriness and the benefits of HLA‐matched platelet transfusions. Blood. 1987;70(1):23–30.
1. Carr R, Hutton JL, Jenkins JA, Lucas GF, Amphlett NW. Transfusion of ABO‐mismatched platelets leads to early platelet refractoriness. Br J Haematol. 1990;75(3):408–413.

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"Epitope-based matching for platelet transfusion overview: Is it time?"-Insights and future directions from the 2024 American Red Cross symposium on platelet component selection

Affiliations

"Epitope-based matching for platelet transfusion overview: Is it time?"-Insights and future directions from the 2024 American Red Cross symposium on platelet component selection

Authors

Affiliations

References

REFERENCES

Publication types

LinkOut - more resources

Full Text Sources