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. 2025 Aug 30:e01294.
doi: 10.1002/cbdv.202501294. Online ahead of print.

Plinia cauliflora Leaf Extract Promotes Wound Healing Through Anti-Inflammatory, Antioxidant, and Antibacterial Actions

Priscila de Lima Paula  1 , Mariana Hauck Vianna  1 , Júlia Bertolini Fajardo  1 , Ana Barbara Polo  1 , Lara Melo Campos  1 , Thayná Gomes Ferreira  1 , Ari Sérgio de Oliveira Lemos  1 , Thalita de Freitas Souza  1 , Lívia Rodrigues Gamarano  1 , Maria Clara Machado Resende Guedes  2 , Samira Aparecida Coelho Souza  3 , Ayrton Senna Pinheiro  4 , Leandro De Santis Ferreira  4 , José Maria Barbosa-Filho  5 , Elaine Soares Coimbra  2 , Gilson Costa Macedo  2 , Luciana Moreira Chedier  3 , Rodrigo Luiz Fabri  1
Affiliations

Plinia cauliflora Leaf Extract Promotes Wound Healing Through Anti-Inflammatory, Antioxidant, and Antibacterial Actions

Priscila de Lima Paula et al. Chem Biodivers. .

Abstract

Plinia cauliflora (DC.) Kausel (jabuticaba) is traditionally used by Brazilian indigenous communities for therapeutic purposes, including the treatment of wounds and inflammation. This study investigated the phytochemical composition and biological activities of an ethanolic extract derived from P. cauliflora leaves (ethanolic extract from P. cauliflora leaves [EEPC]). UHPLC-MS phytochemical analysis revealed 13 active phenolic compounds, with gallic acid being the most prevalent at 319.5 µg/mg extract. EEPC demonstrated significant antioxidant activity (IC50 = 4.42 ± 0.91 µg/mL, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay), reducing reactive oxygen species (ROS) generation by 63% and inhibiting lipid peroxidation by 63.69%. Furthermore, it exhibited anti-inflammatory effects by decreasing IL-1β and TNF-α levels by 40% and 74%, respectively. Antimicrobial activity was observed against Pseudomonas aeruginosa and Candida albicans with a minimum inhibitory concentration (MIC) of 250 µg/mL. EEPC also reduced Staphylococcus aureus biofilm adhesion by 95.40%. Notably, EEPC enhanced fibroblast migration by 95.40%, suggesting its potential for wound healing. These results highlight the therapeutic potential of EEPC and the value of Brazilian biodiversity for biomedical applications.

Keywords: Plinia cauliflora; medicinal plants; phenolic compounds; skin wounds; wound healing.

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