Invasive Neonatal Listeriosis

Abstract

Listeriosis, an invasive disease caused by Listeria monocytogenes, is an uncommon cause of perinatal infection with a high risk of morbidity in neonates. Pregnant persons can acquire this foodborne pathogen from deli meats and unprocessed cheese, placing their neonate at risk. In the past 10 years, whole-genome sequencing has been used to track L monocytogenes isolates from clinical samples and those obtained from food processing facilities in the United States. Over time, use of this robust public health surveillance system may lead to a reduction of invasive listeriosis among immunocompromised patients. This review will summarize the epidemiology, pathogenesis, clinical presentation, management, and outcomes of pregnant persons and neonates with invasive Listeria disease.