French expert consensus statement on diagnosis and management of primary hyperparathyroidism

Marie-Christine Vantyghem¹, Eric Mirallié², Abdallah Al-Salameh³, Sébastien Aubert⁴, Sara Barraud⁵, Gregory Baud⁶, Adrien Ben Hamou⁷, Jean-Philippe Bertocchio⁸, Françoise Borson-Chazot⁹, Benjamin Bouillet¹⁰, Claire Briet¹¹, Camille Buffet⁸, Robert Caiazzo⁶, Catherine Cardot-Bauters¹², Bertrand Cariou¹³, Olivier Chabre¹⁴, Philippe Chanson¹⁵, Judith Charbit¹⁶, Nathalie Chéreau¹⁷, Benjamin Chevalier¹⁸, Cédric Cirenei¹⁹, Lucie Coppin²⁰, Bernard Corvillain²¹, Niki Christou²², Thomas Cuny²³, Désirée Deandreis²⁴, Sophie Deguelte²⁵, Brigitte Delemer⁵, Rachel Desailloud³, Christine Do Cao¹², Gianluca Donatini²⁶, Delphine Drui²⁷, Margot Dupeux²⁸, Stéphanie Espiard¹², Lucile Figueres²⁹, Samuel Frey², Edouard Ghanassia³⁰, Cecile Ghander⁸, Sebastien Gaujoux³¹, Bernard Goichot³², Lionel Groussin³³, Iva Gueorguieva³⁴, Carole Guérin³⁵, Julien Hadoux³⁶, Magalie Haissaguerre³⁷, Héloise Henry³⁸, Elif Hindié³⁹, Pascal Houiller⁴⁰, Arnaud Jannin¹², Véronique Kerlan⁴¹, Marc Klein⁴², Eugénie Koumakis⁴³, Paulina Kuczma⁴⁴, Miriam Ladsous¹², Hélène Lasolle⁹, Maëlle Le Bras⁴⁵, Anne-Lise Lecoq⁴⁶, Madleen Lemaitre⁴⁷, Jean-Christophe Lifante⁴⁸, Agnès Linglart⁴⁹, Antoine Guy Lopez⁵⁰, Charlotte Lussey-Lepoutre⁵¹, Dominique Luton⁵², Luigi Maione¹⁵, Camille Marciniak⁶, Muriel Mathonnet⁵³, Fabrice Menegaux³¹, Arnaud Molin⁵⁴, Helena Mosbah⁵⁵, Claire Nominé-Criqui⁵⁶, Marie-Françoise Odou⁵⁷, David Osman⁵⁸, Nunzia Cinzia Paladino⁵⁹, Clotilde Picart⁶⁰, Pauline Romanet⁶¹, Nicolas Santucci⁶², Nicolas Scheyer⁴², Frédéric Sebag⁵⁹, Emmanuelle Sokol⁶³, David Taieb⁶⁴, Igor Tauveron⁶⁵, Christophe Tresallet⁶⁶, Frédéric Triponez⁶⁷, Bruno Vergès¹⁰, Delphine Vezzosi⁶⁸, Laurent Brunaud⁶⁹, Peter Kamenicky⁷⁰

Affiliations

¹ Endocrinology and Metabolism Department; ENDOCAN network, hôpital Huriez, CHU Lille, Lille University, 59000 Lille, France. Electronic address: mc-vantyghem@chru-lille.fr.
² Chirurgie cancérologique, digestive et endocrinienne, institut des maladies de l'appareil digestif, CHU de Nantes, Nantes université, 44000 Nantes, France.
³ Endocrinology-Diabetology and Nutrition Department, Hall 3-Fontenoy, CHU d'Amiens-Picardie, 80054 Amiens cedex 1, France.
⁴ Institute of Pathology, CHU de Lille, University of Lille, 59000 Lille cedex, France.
⁵ Department of Endocrinology, hôpital Robert-Debré, Reims University Hospital, rue du Général-Koenig, 51100 Reims, France; CRESTIC EA 3804, Reims Champagne-Ardenne University, Moulin de la Housse, 51687 Reims, France.
⁶ General and Endocrine Surgery Department, Huriez Hospital, Lille University Hospital, Lille, France.
⁷ Thyroid and Endocrine Tumors Department, Institute of Endocrinology, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, 75013 Paris, France; Thyroid Unit, American Hospital of Paris, 92200 Neuilly-sur-Seine, France.
⁸ Thyroid and Endocrine Tumors Department, Institute of Endocrinology, Competence Center for Rare Diseases of Calcium and Phosphate Metabolism, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, 75013 Paris, France.
⁹ Endocrinology Federation, hôpital Louis-Pradel, hospices civils de Lyon, université Lyon 1, 28, avenue Doyen-Lépine, 69500 Bron, France.
¹⁰ Department of Endocrinology, Diabetology and Nutrition, Inserm Research Center U1231, Padys Team, CHU de Dijon, University of Burgundy, 21000 Dijon, France.
¹¹ Department of Endocrinology, Diabetes and Metabolic Diseases, Reference Center for Rare Thyroid and Hormone Receptor Diseases, Angers University Hospital, 49933 Angers cedex 09, France; Inserm, CNRS, MITOVASC, équipe CarMe, SFR ICAT, University of Angers, 49000 Angers, France.
¹² Endocrinology and Metabolism Department; ENDOCAN network, hôpital Huriez, CHU Lille, Lille University, 59000 Lille, France.
¹³ CNRS, Inserm, Department of Endocrinology, institut du thorax, CHU de Nantes, Nantes Université, 44000 Nantes, France.
¹⁴ Unité mixte de recherche Inserm-CEA-UGA UMR1036, service d'endocrinologie, CHU de Grenoble-Alpes, université de Grenoble-Alpes, 38043 Grenoble, France.
¹⁵ Service d'endocrinologie et des maladies de la reproduction, centre de référence des maladies rares de l'hypophyse HYPO, Inserm, Endocrine Physiology and Physiopathology, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
¹⁶ Gerontology Department, Broca Hospital, AP-HP, université Paris Cité, Paris, France.
¹⁷ Service de chirurgie générale, endocrinienne et viscérale, hôpital Pitié-Salpétrière, AP-HP, 75651 Paris cedex 13, France.
¹⁸ Service de médecine nucléaire et imagerie fonctionnelle, hôpital Claude-Huriez, CHRU de Lille, université de Lille, Lille, France.
¹⁹ Clinique anesthésie - réanimation et de la douleur, hôpital Huriez, CHU de Lille, 59037 Lille cedex, France.
²⁰ CNRS, Inserm, UMR9020-U1277 - CANTHER - Cancer - Heterogeneity Plasticity and Resistance to Therapies, CHU de Lille, université de Lille, Lille, France.
²¹ Service d'endocrinologue, clinique universitaires de Bruxelles, hôpital Erasme, université Libre de Bruxelles, 1070 Bruxelles, Belgium.
²² Department of Digestive Surgery, CHU de Limoges, 87042 Limoges cedex, France.
²³ Inserm U1409, CRMR HYPO, Department of Endocrinology, hôpital de la Conception, AP-HM, Aix-Marseille University, Marseille, France.
²⁴ Imaging Department, Nuclear Medicine Service, Gustave-Roussy, université Paris-Saclay, 94805 Villejuif, France.
²⁵ Digestive and Endocrine Surgery Department, hôpital Robert-Debré, CHU de Reims, 51100 Reims, France.
²⁶ General and Endocrine Surgery Department, Inserm U1313-IRMETIST, CHU de Poitiers, Poitiers, France.
²⁷ Service d'endocrinologie, diabétologie et Nutrition, institut du thorax, CHU de Nantes, Nantes université, 44000 Nantes, France.
²⁸ Service d'anatomie pathologique, centre hospitalier de Bicêtre, AP-HP, Paris-Saclay University, Paris, France.
²⁹ Institut de transplantation urologie néphrologie (ITUN), CHU de Nantes, Nantes, France; Centre de recherche en transplantation et immunologie UMR 1064, Inserm, université de Nantes, 44093 Nantes, France.
³⁰ Centre de thyroïdologie diagnostique et interventionnelle, polyclinique Sainte-Thérèse, 34200 Sète, France.
³¹ Département de chirurgie viscérale et endocrinienne, hôpital de la Pitié-Salpêtrière, AP-HP, Sorbonne université, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
³² Endocrinology, Diabetology and Nutrition Department, University Hospitals of Strasbourg, Strasbourg University, Strasbourg, France.
³³ Endocrinology Department, Inserm U1016, CNRS UMR 8104, hôpital Cochin, université Paris Cité, Paris, France.
³⁴ Service de pédiatrie, hôpital Jeanne-de-Flandres, CHU de Lille, université de Lille, 59000 Lille, France.
³⁵ Department of General, Endocrine and Metabolic Surgery, La Conception Hospital, Aix-Marseille University, Marseille, France.
³⁶ Endocrine Oncology Service, Imaging Department, ENDOCAN Network, Gustave-Roussy, université Paris-Saclay, 94805 Villejuif, France.
³⁷ Service d'endocrinologie et oncologie endocrinienne, hôpital Haut Lévêque, CHU de Bordeaux, Pessac, France.
³⁸ ULR 7365-Groupe de recherche sur les formes injectables et les technologies associées (GRITA), CHU de Lille, université de Lille, 59000 Lille, France.
³⁹ Department of Nuclear Medicine, CHU de Bordeaux, 33000 Bordeaux, France.
⁴⁰ Laboratoire de physiologie rénale et tubulopathies, CNRS équipe mixte de recherche 8228, Faculty of Medicine, centre de recherche des Cordeliers, institut national de la santé et de la recherche médicale, Sorbonne université, université Paris Cité, 75006 Paris, France; Service de physiologie, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 75015 Paris, France; Center de référence des maladies rares du calcium et du phosphate, The European Reference Network on Rare Endocrine Conditions (Endo-ERN), 75015 Paris, France.
⁴¹ UMR1304 GETBO, Endocrinology and Diabetology Department, CHU de Brest, University of Brest, 29200 Brest, France.
⁴² Endocrinology, Diabetology and Nutrition Department, Nancy University Hospital, University of Lorraine, 54000 Nancy, France.
⁴³ Centre de référence des maladies osseuses rares, institut de rhumatologie, Inserm UMR 1163, hôpital Cochin, Paris, France.
⁴⁴ Service de chirurgie digestive, bariatrique et endocrinienne, CHU Avicenne, université Sorbonne Paris Nord, Assistance publique-Hôpitaux de Paris, Bobigny, France.
⁴⁵ Service d'endocrinologie diabétologie-nutrition, institut du thorax, CHU de Nantes, Nantes université, 44000 Nantes, France.
⁴⁶ Service d'endocrinologie et des maladies de la reproduction, centre de recherche clinique, centre de référence des maladies rares du métabolisme du calcium et du phosphate, Inserm, physiologie et physiopathologie endocriniennes, hôpital Bicêtre, AP-HP, université Paris-Saclay, 94275 Le Kremlin-Bicêtre, France.
⁴⁷ Service de diabétologie-nutrition, METRICS ULR2694, CHU de Lille, hôpital Huriez, université de Lille, 59000 Lille, France.
⁴⁸ Endocrine Surgery Department, centre hospitalier de Lyon Sud, hospices civils de Lyon, université Lyon1, chemin du Grand Revoyet, 69450 Pierre Bénite, France.
⁴⁹ Service d'endocrinologie et de diabétologie pédiatrique, centre de référence des maladies rares du métabolisme du calcium et du phosphate, Inserm, Endocrine Physiology and Physiopathology, Assistance publique-Hôpitaux de Paris, hôpital Bicêtre, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
⁵⁰ Department of Endocrinology, Diabetes and Metabolic Diseases, Inserm, NorDiC UMR 1239, CHU de Rouen, University of Rouen-Normandie, 76000 Rouen, France.
⁵¹ Nuclear Medicine Department, groupe hospitalier Pitié-Salpêtrière, Sorbonne University, Paris, France.
⁵² Service de gynécologie-obstétrique, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
⁵³ General Digestive and Endocrine Surgery, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France; UMR Inserm 1308, faculté de médecine, 2, rue du Docteur-Marcland, 87025 Limoges, France.
⁵⁴ Department of Genetics, Reference Center for Developmental Disorders and Malformative Syndromes, Anddi-Rares Network, UNICAEN, RU7450 BioTARGen, University of Normandy, Caen University Hospital, Caen, France.
⁵⁵ Department of Endocrinology, Diabetology and Nutrition, Inserm, centre d'investigation clinique CIC1402, Poitiers University Hospital, 86021 Poitiers, France.
⁵⁶ Department of Visceral, Metabolic and Cancer Surgery, Inserm NGERE Laboratory, CHU de Nancy, University of Lorraine, 54000 Nancy, France.
⁵⁷ Inserm, U1286 - Infinite, CHU de Lille, University of Lille, 59045 Lille cedex, France; Department of Biochemistry and Molecular Biology, Lille University Hospital, Lille, France.
⁵⁸ Service de médecine intensive réanimation, hôpital Bicêtre, AP-HP, 94275 Le Kremlin-Bicêtre, France.
⁵⁹ Department of General Endocrine and Metabolic Surgery, Conception University Hospital, Aix-Marseille University, 147, boulevard Baille, 13005 Marseille, France.
⁶⁰ Service de gériatrie, hôpital Ambroise-Paré, AP-HP, Boulogne-Billancourt, France.
⁶¹ Laboratory of Molecular Biology GEnOPé, BIOGENOPOLE, Inserm, MMG, AP-HM, La Timone University Hospital, Aix-Marseille University, Marseille, France.
⁶² Department of Digestive, Oncological and Endocrine Surgery, Dijon University Hospital Centre, Dijon, France.
⁶³ Fenarediam, 5, Villa Boissière, 75016 Paris, France.
⁶⁴ Département de médecine nucléaire, CERIMED, hôpital de la Timone, AP-HM, université Aix-Marseille, 264, rue Saint-Pierre, 13385 Marseille, France.
⁶⁵ Endocrinology Diabetology, CHU de Clermont-Ferrand, 58, rue Montalembert, 63000 Clermont-Ferrand, France; Institut Genetics, Reproduction and Development (GReD), CNRS UMR 6293, Inserm U1103, université Clermont-Auvergne, 28, place Henri-Dunant, 63000 Clermont-Ferrand, France.
⁶⁶ Service de chirurgie digestive, bariatrique et endocrinienne, CHU Avicenne, Assistance publique-Hôpitaux de Paris, université Sorbonne Paris Nord, Bobigny, France.
⁶⁷ Department of Surgery, Division of Thoracic Surgery, University Hospitals of Geneva, Faculty of Medicine of the Geneva University, 1205 Geneva, Switzerland.
⁶⁸ Endocrinology, Diabetology and Nutrition Department, CHU Larrey, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse, France.
⁶⁹ Département de chirurgie viscérale, métabolique et cancérologique (CVMC), Inserm U1256 NGERE, CHU de Nancy, université de Lorraine, Nancy, France.
⁷⁰ Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate, 94275 Le Kremlin-Bicêtre, France.

PMID: 40889554
DOI: 10.1016/j.ando.2025.102449

Practice Guideline

French expert consensus statement on diagnosis and management of primary hyperparathyroidism

Marie-Christine Vantyghem et al. Ann Endocrinol (Paris). 2025.

. 2025 Aug 30;86(5):102449.

doi: 10.1016/j.ando.2025.102449. Online ahead of print.

Authors

Affiliations

¹ Endocrinology and Metabolism Department; ENDOCAN network, hôpital Huriez, CHU Lille, Lille University, 59000 Lille, France. Electronic address: mc-vantyghem@chru-lille.fr.
² Chirurgie cancérologique, digestive et endocrinienne, institut des maladies de l'appareil digestif, CHU de Nantes, Nantes université, 44000 Nantes, France.
³ Endocrinology-Diabetology and Nutrition Department, Hall 3-Fontenoy, CHU d'Amiens-Picardie, 80054 Amiens cedex 1, France.
⁴ Institute of Pathology, CHU de Lille, University of Lille, 59000 Lille cedex, France.
⁵ Department of Endocrinology, hôpital Robert-Debré, Reims University Hospital, rue du Général-Koenig, 51100 Reims, France; CRESTIC EA 3804, Reims Champagne-Ardenne University, Moulin de la Housse, 51687 Reims, France.
⁶ General and Endocrine Surgery Department, Huriez Hospital, Lille University Hospital, Lille, France.
⁷ Thyroid and Endocrine Tumors Department, Institute of Endocrinology, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, 75013 Paris, France; Thyroid Unit, American Hospital of Paris, 92200 Neuilly-sur-Seine, France.
⁸ Thyroid and Endocrine Tumors Department, Institute of Endocrinology, Competence Center for Rare Diseases of Calcium and Phosphate Metabolism, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, 75013 Paris, France.
⁹ Endocrinology Federation, hôpital Louis-Pradel, hospices civils de Lyon, université Lyon 1, 28, avenue Doyen-Lépine, 69500 Bron, France.
¹⁰ Department of Endocrinology, Diabetology and Nutrition, Inserm Research Center U1231, Padys Team, CHU de Dijon, University of Burgundy, 21000 Dijon, France.
¹¹ Department of Endocrinology, Diabetes and Metabolic Diseases, Reference Center for Rare Thyroid and Hormone Receptor Diseases, Angers University Hospital, 49933 Angers cedex 09, France; Inserm, CNRS, MITOVASC, équipe CarMe, SFR ICAT, University of Angers, 49000 Angers, France.
¹² Endocrinology and Metabolism Department; ENDOCAN network, hôpital Huriez, CHU Lille, Lille University, 59000 Lille, France.
¹³ CNRS, Inserm, Department of Endocrinology, institut du thorax, CHU de Nantes, Nantes Université, 44000 Nantes, France.
¹⁴ Unité mixte de recherche Inserm-CEA-UGA UMR1036, service d'endocrinologie, CHU de Grenoble-Alpes, université de Grenoble-Alpes, 38043 Grenoble, France.
¹⁵ Service d'endocrinologie et des maladies de la reproduction, centre de référence des maladies rares de l'hypophyse HYPO, Inserm, Endocrine Physiology and Physiopathology, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
¹⁶ Gerontology Department, Broca Hospital, AP-HP, université Paris Cité, Paris, France.
¹⁷ Service de chirurgie générale, endocrinienne et viscérale, hôpital Pitié-Salpétrière, AP-HP, 75651 Paris cedex 13, France.
¹⁸ Service de médecine nucléaire et imagerie fonctionnelle, hôpital Claude-Huriez, CHRU de Lille, université de Lille, Lille, France.
¹⁹ Clinique anesthésie - réanimation et de la douleur, hôpital Huriez, CHU de Lille, 59037 Lille cedex, France.
²⁰ CNRS, Inserm, UMR9020-U1277 - CANTHER - Cancer - Heterogeneity Plasticity and Resistance to Therapies, CHU de Lille, université de Lille, Lille, France.
²¹ Service d'endocrinologue, clinique universitaires de Bruxelles, hôpital Erasme, université Libre de Bruxelles, 1070 Bruxelles, Belgium.
²² Department of Digestive Surgery, CHU de Limoges, 87042 Limoges cedex, France.
²³ Inserm U1409, CRMR HYPO, Department of Endocrinology, hôpital de la Conception, AP-HM, Aix-Marseille University, Marseille, France.
²⁴ Imaging Department, Nuclear Medicine Service, Gustave-Roussy, université Paris-Saclay, 94805 Villejuif, France.
²⁵ Digestive and Endocrine Surgery Department, hôpital Robert-Debré, CHU de Reims, 51100 Reims, France.
²⁶ General and Endocrine Surgery Department, Inserm U1313-IRMETIST, CHU de Poitiers, Poitiers, France.
²⁷ Service d'endocrinologie, diabétologie et Nutrition, institut du thorax, CHU de Nantes, Nantes université, 44000 Nantes, France.
²⁸ Service d'anatomie pathologique, centre hospitalier de Bicêtre, AP-HP, Paris-Saclay University, Paris, France.
²⁹ Institut de transplantation urologie néphrologie (ITUN), CHU de Nantes, Nantes, France; Centre de recherche en transplantation et immunologie UMR 1064, Inserm, université de Nantes, 44093 Nantes, France.
³⁰ Centre de thyroïdologie diagnostique et interventionnelle, polyclinique Sainte-Thérèse, 34200 Sète, France.
³¹ Département de chirurgie viscérale et endocrinienne, hôpital de la Pitié-Salpêtrière, AP-HP, Sorbonne université, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
³² Endocrinology, Diabetology and Nutrition Department, University Hospitals of Strasbourg, Strasbourg University, Strasbourg, France.
³³ Endocrinology Department, Inserm U1016, CNRS UMR 8104, hôpital Cochin, université Paris Cité, Paris, France.
³⁴ Service de pédiatrie, hôpital Jeanne-de-Flandres, CHU de Lille, université de Lille, 59000 Lille, France.
³⁵ Department of General, Endocrine and Metabolic Surgery, La Conception Hospital, Aix-Marseille University, Marseille, France.
³⁶ Endocrine Oncology Service, Imaging Department, ENDOCAN Network, Gustave-Roussy, université Paris-Saclay, 94805 Villejuif, France.
³⁷ Service d'endocrinologie et oncologie endocrinienne, hôpital Haut Lévêque, CHU de Bordeaux, Pessac, France.
³⁸ ULR 7365-Groupe de recherche sur les formes injectables et les technologies associées (GRITA), CHU de Lille, université de Lille, 59000 Lille, France.
³⁹ Department of Nuclear Medicine, CHU de Bordeaux, 33000 Bordeaux, France.
⁴⁰ Laboratoire de physiologie rénale et tubulopathies, CNRS équipe mixte de recherche 8228, Faculty of Medicine, centre de recherche des Cordeliers, institut national de la santé et de la recherche médicale, Sorbonne université, université Paris Cité, 75006 Paris, France; Service de physiologie, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 75015 Paris, France; Center de référence des maladies rares du calcium et du phosphate, The European Reference Network on Rare Endocrine Conditions (Endo-ERN), 75015 Paris, France.
⁴¹ UMR1304 GETBO, Endocrinology and Diabetology Department, CHU de Brest, University of Brest, 29200 Brest, France.
⁴² Endocrinology, Diabetology and Nutrition Department, Nancy University Hospital, University of Lorraine, 54000 Nancy, France.
⁴³ Centre de référence des maladies osseuses rares, institut de rhumatologie, Inserm UMR 1163, hôpital Cochin, Paris, France.
⁴⁴ Service de chirurgie digestive, bariatrique et endocrinienne, CHU Avicenne, université Sorbonne Paris Nord, Assistance publique-Hôpitaux de Paris, Bobigny, France.
⁴⁵ Service d'endocrinologie diabétologie-nutrition, institut du thorax, CHU de Nantes, Nantes université, 44000 Nantes, France.
⁴⁶ Service d'endocrinologie et des maladies de la reproduction, centre de recherche clinique, centre de référence des maladies rares du métabolisme du calcium et du phosphate, Inserm, physiologie et physiopathologie endocriniennes, hôpital Bicêtre, AP-HP, université Paris-Saclay, 94275 Le Kremlin-Bicêtre, France.
⁴⁷ Service de diabétologie-nutrition, METRICS ULR2694, CHU de Lille, hôpital Huriez, université de Lille, 59000 Lille, France.
⁴⁸ Endocrine Surgery Department, centre hospitalier de Lyon Sud, hospices civils de Lyon, université Lyon1, chemin du Grand Revoyet, 69450 Pierre Bénite, France.
⁴⁹ Service d'endocrinologie et de diabétologie pédiatrique, centre de référence des maladies rares du métabolisme du calcium et du phosphate, Inserm, Endocrine Physiology and Physiopathology, Assistance publique-Hôpitaux de Paris, hôpital Bicêtre, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
⁵⁰ Department of Endocrinology, Diabetes and Metabolic Diseases, Inserm, NorDiC UMR 1239, CHU de Rouen, University of Rouen-Normandie, 76000 Rouen, France.
⁵¹ Nuclear Medicine Department, groupe hospitalier Pitié-Salpêtrière, Sorbonne University, Paris, France.
⁵² Service de gynécologie-obstétrique, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris, Université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France.
⁵³ General Digestive and Endocrine Surgery, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France; UMR Inserm 1308, faculté de médecine, 2, rue du Docteur-Marcland, 87025 Limoges, France.
⁵⁴ Department of Genetics, Reference Center for Developmental Disorders and Malformative Syndromes, Anddi-Rares Network, UNICAEN, RU7450 BioTARGen, University of Normandy, Caen University Hospital, Caen, France.
⁵⁵ Department of Endocrinology, Diabetology and Nutrition, Inserm, centre d'investigation clinique CIC1402, Poitiers University Hospital, 86021 Poitiers, France.
⁵⁶ Department of Visceral, Metabolic and Cancer Surgery, Inserm NGERE Laboratory, CHU de Nancy, University of Lorraine, 54000 Nancy, France.
⁵⁷ Inserm, U1286 - Infinite, CHU de Lille, University of Lille, 59045 Lille cedex, France; Department of Biochemistry and Molecular Biology, Lille University Hospital, Lille, France.
⁵⁸ Service de médecine intensive réanimation, hôpital Bicêtre, AP-HP, 94275 Le Kremlin-Bicêtre, France.
⁵⁹ Department of General Endocrine and Metabolic Surgery, Conception University Hospital, Aix-Marseille University, 147, boulevard Baille, 13005 Marseille, France.
⁶⁰ Service de gériatrie, hôpital Ambroise-Paré, AP-HP, Boulogne-Billancourt, France.
⁶¹ Laboratory of Molecular Biology GEnOPé, BIOGENOPOLE, Inserm, MMG, AP-HM, La Timone University Hospital, Aix-Marseille University, Marseille, France.
⁶² Department of Digestive, Oncological and Endocrine Surgery, Dijon University Hospital Centre, Dijon, France.
⁶³ Fenarediam, 5, Villa Boissière, 75016 Paris, France.
⁶⁴ Département de médecine nucléaire, CERIMED, hôpital de la Timone, AP-HM, université Aix-Marseille, 264, rue Saint-Pierre, 13385 Marseille, France.
⁶⁵ Endocrinology Diabetology, CHU de Clermont-Ferrand, 58, rue Montalembert, 63000 Clermont-Ferrand, France; Institut Genetics, Reproduction and Development (GReD), CNRS UMR 6293, Inserm U1103, université Clermont-Auvergne, 28, place Henri-Dunant, 63000 Clermont-Ferrand, France.
⁶⁶ Service de chirurgie digestive, bariatrique et endocrinienne, CHU Avicenne, Assistance publique-Hôpitaux de Paris, université Sorbonne Paris Nord, Bobigny, France.
⁶⁷ Department of Surgery, Division of Thoracic Surgery, University Hospitals of Geneva, Faculty of Medicine of the Geneva University, 1205 Geneva, Switzerland.
⁶⁸ Endocrinology, Diabetology and Nutrition Department, CHU Larrey, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse, France.
⁶⁹ Département de chirurgie viscérale, métabolique et cancérologique (CVMC), Inserm U1256 NGERE, CHU de Nancy, université de Lorraine, Nancy, France.
⁷⁰ Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate, 94275 Le Kremlin-Bicêtre, France.

PMID: 40889554
DOI: 10.1016/j.ando.2025.102449

Abstract

In 2024, the French Society of Endocrinology, the French-speaking Association of Endocrine Surgery, and the French Society of Nuclear Medicine have elaborated a joint consensus statement on primary hyperparathyroidism, which was presented at the last congress of the French Society of Endocrinology, in October 2024, and subsequently published as 15 individual chapters in the Annals of Endocrinology. This consensus statement is a fruit of a joint effort by over 80 French-speaking experts in the field, including adult and pediatric endocrinologists, endocrine and pediatric surgeons, radiologists, nuclear medicine specialists, biologists and geneticists, and has been endorsed by the Belgian and Swiss endocrine societies. This document summarizes the recommendations, subdivided into 15 sections each preceded by a brief introduction. It aimed at covering systematically all areas of diagnosis and management of primary hyperparathyroidism throughout life in a comprehensive way, that we hope could be useful in particular to our younger colleagues in training.

Keywords: Atypical parathyroid adenoma; Cure-recurrence-persistence-parathyromatosis; Diagnosis; Differential diagnosis; Epidemiology; Follow-up; Genetic predisposition; Histopathology; Lactation; Parathyroid carcinoma; Parathyroid imaging; Pediatric forms; Pregnancy; Primary hyperparathyroidism; Severe hypercalcemia; Syndromic forms; Target-organ complications; Therapeutic indications.

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Disclosure of interest The authors declare that they have no competing interest.

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French expert consensus statement on diagnosis and management of primary hyperparathyroidism

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French expert consensus statement on diagnosis and management of primary hyperparathyroidism

Authors

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Abstract

Conflict of interest statement

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