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Review
. 2025 Sep 2.
doi: 10.1002/ana.78016. Online ahead of print.

Neurosyphilis

Daniel J Minter  1 , Felicia C Chow  1   2
Affiliations
Review

Neurosyphilis

Daniel J Minter et al. Ann Neurol. .

Abstract

Neurosyphilis remains an important and highly morbid neurologic infection. Recent years have seen a dramatic increase in the incidence of syphilis across a variety of populations, making recognition of the many neurologic complications of this infection still relevant for modern clinicians. As manifestations of neurosyphilis are famously varied, a high index of suspicion is essential, especially in the face of atypical presentations. In this review, we discuss updates to the epidemiology, range of clinical presentations, diagnosis, and management of neurosyphilis. ANN NEUROL 2025.

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References

    1. Ghanem KG. REVIEW: neurosyphilis: a historical perspective and review. CNS Neurosci Ther 2010;16:e157–e168.
    1. National Overview of STIs in 2023, Available at: https://www.cdc.gov/sti-statistics/annual/index.html.
    1. de Voux A, Kidd S, Torrone EA. Reported cases of neurosyphilis among early syphilis cases‐United States, 2009 to 2015. Sex Transm Dis 2018;45:39–41.
    1. Dombrowski JC, Pedersen R, Marra CM, et al. Prevalence estimates of complicated syphilis. Sex Transm Dis 2015;42:702–704.
    1. Jackson DA, McDonald R, Quilter LAS, et al. Reported neurologic, ocular, and Otic manifestations among syphilis Cases‐16 states, 2019. Sex Transm Dis 2022;49:726–732.

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