doi: 10.1016/0278-5846(85)90052-1.
Behavioral and neurochemical effects of (-)- and (+/-)-cathinone: dose-response and time-course
- PMID: 4089202
- DOI: 10.1016/0278-5846(85)90052-1
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Behavioral and neurochemical effects of (-)- and (+/-)-cathinone: dose-response and time-course
Prog Neuropsychopharmacol Biol Psychiatry.
1985.
Abstract
The purpose of the present study was to compare (-)-cathinone and its analogue (+/-)-cathinone using behavioral and neurochemical measures. Rats were trained to discriminate between 0.6 mg/kg (-)- or (+/-)-cathinone and saline in a food-motivated, two-lever operant task. In addition, concentrations of dopamine, norepinephrine, 5-hydroxytryptamine and their major metabolites were analyzed in the nuclei accumbens and septi lateralis. The results suggest that (-)- and (+/-)-cathinone have similar effects on behavior and neurochemistry with (-)-cathinone being more potent.
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