Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Sep 2;41(9):320.
doi: 10.1007/s11274-025-04536-y.

Recent trends in microbial production of alkanes

Affiliations
Review

Recent trends in microbial production of alkanes

Noura Sh A Hagaggi et al. World J Microbiol Biotechnol. .

Abstract

Alkanes are saturated hydrocarbons characterized by their stable chemical properties and multiple uses in the energy sector. Although alkanes are found in nature in various sources like natural gas and petroleum, microbial alkane production has become a promising way to develop sustainable biofuels. Alkanes are produced by microorganisms such as bacteria, fungi, yeast, and algae via particular metabolic pathways. Although progress has been achieved, challenges remain, including low conversion efficiencies and excessive costs of biofuel production compared to conventional fossil fuels, along with the need to enhance microbial resistance to harsh production conditions. By understanding current progress and future challenges, researchers and bioengineers can develop modern technologies and methods to improve the efficiency and effectiveness of microbial alkane production. This review provides a detailed look at the recent developments in microbial biosynthesis of alkanes, highlighting the key metabolic pathways and genetic techniques used to scale up production. It also discusses the challenges and obstacles facing the production of microbial alkanes. The review emphasizes the role of microbial alkane production in promoting a sustainable energy future. This review may enhance awareness of the importance of developing renewable biofuel sources, which supports global efforts to combat climate change and achieve sustainable development.

Keywords: Alkane; Biofuel; Development; Microbial production; Sustainable.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The overall microbial production of alkanes
Fig. 2
Fig. 2
Schemes of microbial alkanes biosynthesis pathways: Cyanobacteria (Li et al. 2012), Escherichia coli (Song et al. 2016), and Saccharomyces cerevisiae (Kang et al. 2017)

Similar articles

References

    1. Agarwal P, Soni R, Kaur P, Madan A, Mishra R, Pandey J, Singh S, Singh G (2022) Cyanobacteria as a promising alternative for sustainable environment: synthesis of biofuel and biodegradable plastics. Front Microbiol 13:939347. 10.3389/fmicb.2022.939347 - PMC - PubMed
    1. Akhtar MK, Turner NJ, Jones PR (2013) Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities. Proc Natl Acad Sci USA 110(1):87–92. 10.1073/pnas.1216516110 - PMC - PubMed
    1. Andre C, Kim SW, Yu XH, Shanklin J (2013) Fusing catalase to an alkane-producing enzyme maintains enzymatic activity by converting the inhibitory byproduct H2O2 to the cosubstrate O2. Proc Natl Acad Sci U S A 110(8):3191–3196. 10.1073/pnas.1218769110 - PMC - PubMed
    1. Ansori AN, Antonius Y, Susilo RJ, Hayaza S, Kharisma VD, Parikesit AA, Zainul R, Jakhmola V, Saklani T, Rebezov M, Ullah ME, Maksimiuk N, Derkho M, Burkov P (2023) Application of CRISPR-Cas9 genome editing technology in various fields: A review. Narra J 3(2):e184. 10.52225/narra.v3i2.184 - PMC - PubMed
    1. Azimov U, Okoro V, Hernandez HH (2021) Recent progress and trends in the development of microbial biofuels from solid Waste- A review. Energies 14(19):6011. 10.3390/en14196011

LinkOut - more resources