Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep 1;15(9):8703-8708.
doi: 10.21037/qims-2025-176. Epub 2025 Aug 11.

Endoscopic endonasal transsphenoidal approach of pituitary macroadenoma and optic canal stenosis in a patient with McCune-Albright syndrome

Affiliations

Endoscopic endonasal transsphenoidal approach of pituitary macroadenoma and optic canal stenosis in a patient with McCune-Albright syndrome

Leonardo A S Beck et al. Quant Imaging Med Surg. .
No abstract available

Keywords: McCune-Albright; bone dysplasia; optic canal; pituitary macroadenoma.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-2025-176/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Sagittal T2-weighted MRI illustrating a pituitary macroadenoma in the patient (red arrow). MRI, magnetic resonance imaging.
Figure 2
Figure 2
Axial tomography imaging of facial bones. There is considerable osseous enlargement with regions of varied bone density ranging from sclerotic to lucent. The majority of affected bones exhibit a ground-glass appearance.
Figure 3
Figure 3
Axial T2-weighted MRI. Notice the involvement of the optic canal (red arrows). MRI, magnetic resonance imaging.
Figure 4
Figure 4
Coronal T1-weighted Gd MRI illustrating a pituitary macroadenoma touching the optic chiasm, with left parasellar extension (left side). Gd, gadolinium; MRI, magnetic resonance imaging.
Figure 5
Figure 5
Intraoperative endoscopic view demonstrating a narrowed left nasal fossa. *, indicates inferior turbinate; #, indicates nasal septum.
Figure 6
Figure 6
Endoscopic intraoperative image depicting the surgical drilling of the extensively ossified sphenoid sinus.
Figure 7
Figure 7
Endoscopic intraoperative images illustrating the exposure of the dura mater overlying the sellar region and the optic canal, following drilling of the sphenoid sinus (A); the initiation of pituitary adenoma resection (B) and the final aspect of the sellar region after gross total resection of the pituitary adenoma (C). *, indicates optic canal; #, indicates sellar region.
Figure 8
Figure 8
Endoscopic intraoperative image illustrating the exposure of the dura mater overlying the sellar region and the optic canal, following drilling of the sphenoid sinus. *, indicates optic canal; #, indicates sellar region.
Figure 9
Figure 9
Endoscopic intraoperative image showing the initiation of pituitary adenoma resection.
Figure 10
Figure 10
Endoscopic intraoperative image showing the final aspect of the sellar region after gross total resection of the pituitary adenoma.

References

    1. Chapurlat RD, Orcel P. Fibrous dysplasia of bone and McCune-Albright syndrome. Best Pract Res Clin Rheumatol 2008;22:55-69. 10.1016/j.berh.2007.11.004 - DOI - PubMed
    1. Albright F, Butler AM, Hampton AO, Smith PH. Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females: report of five cases. N Engl J Med 1937;216:727-46.
    1. Chen YR, Breidahl A, Chang CN. Optic nerve decompression in fibrous dysplasia: indications, efficacy, and safety. Plast Reconstr Surg 1997;99:22-30; discussion 31-3. 10.1097/00006534-199701000-00004 - DOI - PubMed
    1. Sammut SJ, Kandasamy J, Newman W, Sinha A, Ross J, Blair JC, May P. Relief of severe retro-orbital pain and vision improvement after optic-nerve decompression in polyostotic fibrous dysplasia: case report and review of the literature. Childs Nerv Syst 2008;24:515-20. 10.1007/s00381-007-0543-y - DOI - PubMed
    1. Horvath E, Kovacs K, Killinger DW, Smyth HS, Weiss MH, Ezrin C. Mammosomatotroph cell adenoma of the human pituitary: a morphologic entity. Virchows Arch A Pathol Anat Histopathol 1983;398:277-89. 10.1007/BF00583585 - DOI - PubMed

LinkOut - more resources