Balancing efficacy and tolerability in metastatic pancreatic cancer: lessons from the ALPACA trial
- PMID: 40893742
- PMCID: PMC12393121
- DOI: 10.21037/hbsn-2025-315
Balancing efficacy and tolerability in metastatic pancreatic cancer: lessons from the ALPACA trial
Keywords: Nab-paclitaxel; dose-reduction strategy; gemcitabine; maintenance chemotherapy; metastatic pancreatic cancer.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-2025-315/coif). The authors have no conflicts of interest to declare.
Comment on
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Alternating gemcitabine plus nab-paclitaxel and gemcitabine alone versus continuous gemcitabine plus nab-paclitaxel after induction treatment of metastatic pancreatic cancer (ALPACA): a multicentre, randomised, open-label, phase 2 trial.Lancet Gastroenterol Hepatol. 2024 Oct;9(10):935-943. doi: 10.1016/S2468-1253(24)00197-3. Epub 2024 Aug 16. Lancet Gastroenterol Hepatol. 2024. PMID: 39159648 Clinical Trial.
References
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- Dorman K, Boeck S, Caca K, et al. Alternating gemcitabine plus nab-paclitaxel and gemcitabine alone versus continuous gemcitabine plus nab-paclitaxel after induction treatment of metastatic pancreatic cancer (ALPACA): a multicentre, randomised, open-label, phase 2 trial. Lancet Gastroenterol Hepatol 2024;9:935-43. 10.1016/S2468-1253(24)00197-3 - DOI - PubMed
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