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Editorial
. 2025 Aug 1;14(4):647-650.
doi: 10.21037/hbsn-2025-238. Epub 2025 Jul 25.

De-escalating local therapies without compromising outcomes: lessons from the COLLISION trial

Jessica Albuquerque  1 , Noreen S Siddiqi  1 , Van K Morris  2 , Hop Tran Cao  3 , Iwan Paolucci  1 , Bruno C Odisio  1
Affiliations
Editorial

De-escalating local therapies without compromising outcomes: lessons from the COLLISION trial

Jessica Albuquerque et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Liver; ablation techniques; colorectal neoplasm; hepatectomy; survival analysis.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-2025-238/coif). V.K.M. reports funding from BMS, Pfizer, AmMax Bio, and BioNTech, consulting fees from Pfizer, Scandion Oncology, Incyte, and AmMax Bio (Advisory Board) and honorarium from BMS for a lecture, and he serves as DSMB Chair for Incyte. I.P. reports grant support from the Swiss National Science Foundation (P500PM_210871, P2BEP3_195444). B.C.O. reports research grants from Siemens Healthineers and Ethicon. The other authors have no conflicts of interest to declare.

Comment on

  • Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial.
    van der Lei S, Puijk RS, Dijkstra M, Schulz HH, Vos DJW, De Vries JJJ, Scheffer HJ, Lissenberg-Witte BI, Aldrighetti L, Arntz M, Barentsz MW, Besselink MG, Bracke B, Bruijnen RCG, Buffart TE, Burgmans MC, Chapelle T, Coolsen MME, de Boer SW, de Cobelli F, de Jong K, de Wilt JHW, Diederik AL, Dooper AMC, Draaisma WA, Eker HH, Erdmann JI, Futterer JJ, Geboers B, Groot GMC, Hagendoorn J, Hartgrink HH, Horsthuis K, Hurks R, Jenniskens SFM, Kater M, Kazemier G, Kist JW, Klaase JM, Knapen RRMM, Kruimer JWH, Lamers ABGN, Leclercq WKG, Liefers GJ, Manusama ER, Meier MAJ, Melenhorst MCAM, Mieog JSD, Molenaar QI, Nielsen K, Nijkamp MW, Nieuwenhuijs VB, Nota IMGC, Op de Beeck B, Overduin CG, Patijn GA, Potters FH, Ratti F, Rietema FJ, Ruiter SJS, Schouten EAC, Schreurs WH, Serafino G, Sietses C, Slooter GD, Smits MLJ, Soykan EA, Spaargaren GJ, Stommel MWJ, Timmer FEF, van Baardewijk LJ, van Dam RM, van Delden OM, van den Bemd BAT, van den Bergh JE, van den Boezem PB, van der Leij C, van der Meer RW, van der Meijs BBM, van der Ploeg APT, van der Reijden JJ, van Duijvendijk P, van Erkel AR, van Geel AM, Van Heek NT, van Manen CJ, van Rijswijk CSP, van Waesberghe JHTM, Versteeg KS, Vink T, Zijl… See abstract for full author list ➔ van der Lei S, et al. Lancet Oncol. 2025 Feb;26(2):187-199. doi: 10.1016/S1470-2045(24)00660-0. Epub 2025 Jan 20. Lancet Oncol. 2025. PMID: 39848272 Clinical Trial.

References

    1. Benson APV AB, Adam M, Chang GJ, et al. National Comprehensive Cancer Network. Colon Cancer, Version 4.2025. Accessed July 24, 2025. Available online: https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf
    1. Tinguely P, Ruiter SJS, Engstrand J, et al. A prospective multicentre trial on survival after Microwave Ablation VErsus Resection for Resectable Colorectal liver metastases (MAVERRIC). Eur J Cancer 2023;187:65-76. 10.1016/j.ejca.2023.03.038 - DOI - PubMed
    1. van der Lei S, Puijk RS, Dijkstra M, et al. Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial. Lancet Oncol 2025;26:187-99. 10.1016/S1470-2045(24)00660-0 - DOI - PubMed
    1. Puijk RS, Dijkstra M, van den Bemd BAT, et al. Improved Outcomes of Thermal Ablation for Colorectal Liver Metastases: A 10-Year Analysis from the Prospective Amsterdam CORE Registry (AmCORE). Cardiovasc Intervent Radiol 2022;45:1074-89. 10.1007/s00270-022-03152-9 - DOI - PMC - PubMed
    1. Lin YM, Paolucci I, Brock KK, et al. Image-Guided Ablation for Colorectal Liver Metastasis: Principles, Current Evidence, and the Path Forward. Cancers (Basel) 2021;13:3926. 10.3390/cancers13163926 - DOI - PMC - PubMed

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