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Case Reports
. 2025 Aug 20:62:103171.
doi: 10.1016/j.eucr.2025.103171. eCollection 2025 Sep.

Non-functional oncocytic adrenocortical carcinoma: Case report with clinicopathologic and surgical correlation

Induparkavi Murugesan  1 , Vikas Kailashiya  1 , Sahil Data  2 , Madan Gopal Bhardwaj  2 , Sameer Trivedi  2
Affiliations
Case Reports

Non-functional oncocytic adrenocortical carcinoma: Case report with clinicopathologic and surgical correlation

Induparkavi Murugesan et al. Urol Case Rep. .

Abstract

Oncocytic adrenocortical carcinoma (OACC) is a rare variant of adrenocortical carcinoma composed predominantly of oncocytic cells. We present the case of a 45-year-old female with a large, non-functional left adrenal mass diagnosed as OACC. Imaging revealed a well-defined, vascular, heterogeneously enhancing mass without metastasis. Histopathology showed oncocytic cells disposed in nests and sheets with capsular and venous invasion, with low mitotic activity. Surgical excision was curative, and the patient remains disease-free at 10 months. This case highlights the diagnostic and prognostic utility of histologic scoring systems and underlines the role of surgery as the primary treatment in localized OACC.

Keywords: Adrenalectomy; Histopathology; Immunohistochemistry; Incidentaloma; Oncocytic adrenocortical carcinoma; Oncoytic neoplasm.

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Figures

Fig. 1
Fig. 1
Oncocytic adrenocortical carcinoma. CT shows central necrosis and surrounding heterogeneously enhancing solid tumour with maintained fat planes.
Fig. 2
Fig. 2
Oncocytic adrenocortical carcinoma. A. Intra-operative finding. B. Gross examination C. Cut surface.
Fig. 3
Fig. 3
Oncocytic adrenocortical carcinoma. A. Cells disposed in sheets (H and E stain, 10x), B. Cells showing abundant granular eosinophilic cytoplasm. (H and E stain, 40x), C. Vascular invasion (H and E stain, 20x). Reticulin framework disruption (D. 20x, E. 40x). F. Melan A IHC (40x).
See this image and copyright information in PMC

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