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. 2025 Jun 30;9(9):100694.
doi: 10.1016/j.shj.2025.100694. eCollection 2025 Sep.

Reverse Remodeling Induced by Transcatheter Left Ventricular Restoration System Is Sustained Through 2 Years of Follow-Up

Alena Kurlianskaya  1 , Michael L Chuang  2 , Oleg Polonetsky  1 , Olesya Shatova  1 , Jason R Foerst  3 , Kendra J Grubb  4 , Martin B Leon  2   5 , Ulrich P Jorde  6 , Mark Reisman  7 , Daniel Burkhoff  2 ; AccuCinch Study Investigators
Affiliations

Reverse Remodeling Induced by Transcatheter Left Ventricular Restoration System Is Sustained Through 2 Years of Follow-Up

Alena Kurlianskaya et al. Struct Heart. .

Abstract

•Initial structural remodeling, indexed by decreases in left ventricular end-diastolic volume, induced by the Transcatheter Left Ventricular Restoration System is followed by a period of biological reverse remodeling that plateaus after about 6 months and is maintained at least through 2 years.•These structural changes are associated with ∼5% (absolute) increases in left ventricular ejection fraction.•These changes occur in the backdrop of relatively few changes in heart failure medical therapy.•These changes are also associated with improvement of quality of life, though this observation needs to be considered in the context of the current unblinded study.

Keywords: Heart failure; KCCQ; Left ventricle; Left ventricular volume; Remodeling; Transcatheter.

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Conflict of interest statement

A. Kurlianskaya, U. P. Jorde, O. Polonetsky, and M. Reisman receive travel reimbursement from Ancora Heart. O. Polonetsky is a proctor for Ancora Heart. J. R. Foerst and K. J. Grubb are members of the CORCINCH-HF Subject Eligibility Committee. K. J. Grubb is an employee of Medtronic. M. L. Chuang and D. Burkhoff are employees of the Cardiovascular Research Foundation, which receives institutional support from Ancora Heart, but they receive no direct compensation. The other author had no conflicts to declare.

Figures

Figure 1
Figure 1
Changes of LV end-diastolic volume (ΔEDV, red circles) and LVEF (ΔLVEF, blue squares) as a function of follow-up time. Data are mean ± SEM; N indicates the number of paired samples at each timepoint. Abbreviations: EDV, end-diastolic volume; EF, ejection fraction; LV, left ventricular; LVEF, left ventricular ejection fraction; SEM, standard error of the mean.
See this image and copyright information in PMC

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