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. 2025 Sep 3:e202500406.
doi: 10.1002/cplu.202500406. Online ahead of print.

Formosulfathiazole: A Structural Revision

Claudio Maestri  1   2 , Toni Grell  3 , Fabio Travagin  1 , Christian R Göb  4 , Michele Castaldi  5 , Ivana Miletto  1 , Geo Paul  6 , Silvia Zampini  3 , Marco Vandone  3 , Valentina Colombo  3 , Giovanni B Giovenzana  1
Affiliations

Formosulfathiazole: A Structural Revision

Claudio Maestri et al. Chempluschem. .

Abstract

Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.

Keywords: cyclodimer; cyclophane; electron diffraction; formosulfathiazole; structural revision.

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References

    1. Martindale: The Complete Drug Reference (Ed.A. Brayfield), Pharmaceutical Press, London 2014.
    1. M. Williams, Drug Dev. Res. 2013, 74, 339.
    1. L. Brunton, B. Knollmann, Goodman and Gilman's the Pharmacological Basis of Therapeutics, 14th ed., McGraw Hill/Medical, New York 2022.
    1. S. S. Bhatnagar, F. Fernandes, Nature 1949, 164, 272.
    1. J. E. Riviere, M. G. Papich, Veterinary Pharmacology and Therapeutics, Blackwell Pub, Hoboken, NJ 2018.