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. 2025 Oct;33(10):299-306.
doi: 10.1007/s12471-025-01979-8. Epub 2025 Sep 3.

ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration

Annelot J L Peijster  1   2 , Floris J Heinen  3   4 , Sabrine Douiyeb  5 , Michelle D van der Stoel  6 , Jasper L Selder  5 , Anouk G W Watson-de Lepper  7 , Patrick Houthuizen  7 , Matthijs F L Meijs  8 , Linda M Kampschreur  9 , Simon Schalla  10 , Bhanu N M Sinha  11 , Annelies L M Bakker  12 , Ilse J E Kouijzer  13 , Francisca Nijland  14 , C H Edwin Boel  4 , Robert K Riezebos  15 , Mariëlle G J Duffels  16 , Jesper Hjortnaes  17 , Robert J M Klautz  5   17 , Nelianne J Verkaik  18 , Marco C Post  4   19 , Steven A J Chamuleau  5 , Otto Kamp  5 , Wilco Tanis  5   3
Affiliations

ENDOCOR: a nationwide consortium of endocarditis teams-initiating a registry for infective endocarditis within the Netherlands Heart Registration

Annelot J L Peijster et al. Neth Heart J. 2025 Oct.

Abstract

Background: Despite advancements in diagnostics and treatment strategies, infective endocarditis continues to carry a substantial morbidity and mortality risk. In addition, the field of infective endocarditis contains many gaps in evidence, as international guidelines are predominantly based on low-level evidence. To improve infective endocarditis care and survival rates in the Netherlands, adequate evaluation of diagnostics, treatment strategies and outcomes is essential.

Methods: To address this need, a new infective endocarditis registry has been developed by the multidisciplinary ENDOCOR working group with the aim of facilitating nationwide quality control, improving infective endocarditis patient care, and contributing to the numerous gaps in evidence. To optimize data collection, facilitated by the Netherlands Heart Registration (NHR), a pilot project was launched in January 2023 across three selected hospitals.

Results: The findings from the first 150 registered patients were presented to highlight the registry's potential. Following the pilot, many more centres have initiated data collection, demonstrating national engagement and scalability of the initiative.

Conclusion: This article outlines the purpose of ENDOCOR, presents initial pilot data and illustrates the potential of the new national infective endocarditis registry to enhance patient care and support future research.

Keywords: Clinical equipoise; Endocor; First national data; Gaps in evidence; Infective endocarditis; Registry.

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Conflict of interest statement

Conflict of interest: A.J.L. Peijster, F.J. Heinen, S. Douiyeb, M.D. van der Stoel, J.L. Selder, A.G.W. Watson-de Lepper, P. Houthuizen, M.F.L. Meijs, L.M. Kampschreur, S. Schalla, B.N.M. Sinha, A.L.M. Bakker, I.J.E. Kouijzer, F. Nijland, C.H. E. Boel, R.K. Riezebos, M.G.J. Duffels, J. Hjortnaes, R.J.M. Klautz, N.J. Verkaik, O. Kamp and W. Tanis declare that they have no competing interests. S.A.J. Chamuleau and M.C. Post are editors of the Netherlands Heart Journal.

Figures

Fig. 1
Fig. 1
Levels of evidence in the ESC guideline of the management of IE. ESC European Society of Cardiology, IE infective endocarditis. *This category includes surgical indications after neurological complications. **This category includes pacing indication after conduction complications
Fig. 2
Fig. 2
Pillars of the IE working group ENDOCOR. IE infective endocarditis, SBE subacute bacterial endocarditis
Fig. 3
Fig. 3
First results pilot phase new IE registry (01/2023 to 08/2023). IE infective endocarditis, S. aureus Staphylococcus aureus, E. faecalis/faecium Enterococcus faecalis/faecium, CIED cardiovascular implanted electronic device, cm centimeters.* ‘Other’ consists of all causative pathogens besides the ones mentioned above, as well as an unknown result. ** Please note that the CIED group consists of device endocarditis only (pocket infections are not reported here). *** ‘Invasive intervention’ encompasses both CIED extractions and cardiac surgery
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