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Review
. 2025 Sep 1;13(9):e70820.
doi: 10.1002/fsn3.70820. eCollection 2025 Sep.

Neem (Azadirachta indica): A Miracle Herb; Panacea for All Ailments

Tabussam Tufail  1   2 , Huma Bader Ul Ain  2   3 , Aiman Ijaz  2 , Muhammad Adnan Nasir  4 , Ali Ikram  5 , Sana Noreen  2 , Muhammad Tayyab Arshad  5   6 , Muhammed Adem Abdullahi  7
Affiliations
Review

Neem (Azadirachta indica): A Miracle Herb; Panacea for All Ailments

Tabussam Tufail et al. Food Sci Nutr. .

Abstract

The neem tree (Azadirachta indica), native to the Indian subcontinent, has recently gained global recognition because of its extensive therapeutic qualities. It contains a high concentration of antioxidants and other valuable active substances including azadirachtin, salannin, nimbidin, nimbolinin, nimbidol, nimbin, and quercetin, which are extracted from various plant parts. It has been widely utilized in Ayurveda, Unani, and Homeopathic treatments and has gained significant attention in modern medicine. Traditionally, neem leaves, flowers, seeds, fruits, roots, twigs, and bark have been used to treat fever, infection, skin conditions, and dental problems. The immunomodulatory, antiviral, anti-ulcer, antioxidant, anti-inflammatory, antihyperglycemic, antifungal, and anti-carcinogenic properties of neem and its components are well known. This comprehensive review highlights the diverse phytochemicals derived from neem leaves, extraction techniques, and their medicinal value in treating of multiple medical conditions. This miraculous plant has significant potential for enhancing its effectiveness. People have appropriately referred to it as a "natural remedy for numerous illnesses."

Keywords: Azadirachta indica; antioxidant; herb; neem.

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Conflict of interest statement

The authors have nothing to report.The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Neem tree and its different parts (A–D).
FIGURE 2
FIGURE 2
Chemical structure of main bioactive compounds of neem.
FIGURE 3
FIGURE 3
Therapeutic applications of neem.
FIGURE 4
FIGURE 4
Neem's anticancer mechanism action.
FIGURE 5
FIGURE 5
Antidiabetic mechanism action of neem.
FIGURE 6
FIGURE 6
Wound healing mechanism action of neem.
FIGURE 7
FIGURE 7
Neem role in teeth health.
See this image and copyright information in PMC

References

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