doi: 10.1016/j.ejso.2025.110379.
Online ahead of print.
Enhanced recovery and survival after elective surgery for colorectal cancer - propensity score weighting analysis of 2,865 prospective patients
Collaborators,
Affiliations
Collaborators
-
Italian ColoRectal Anastomotic Leakage (iCral) study group:
Paolo Ciano 1 , Michele Benedetti 1 , Leonardo Antonio Montemurro 1 , Maria Sole Mattei 1 , Elena Belloni 1 , Matteo Di Carlo 1 , Daniela Apa 1 , Marco Clementi 9 , Lorenzo Pandolfini 10 , Alessandro Falsetto 10 , Michele Simone 4 , Ugo Pace 5 , Andrea Fares Bucci 5 , Elisa Bertocchi 6 , Gaia Masini 6 , Massimo Giuseppe Viola 11 , Amedeo Altamura 11 , Francesco Rubichi 11 , Ferdinando Ficari 12 , Francesco Giudici 12 , Fabio Cianchi 12 , Felice Pirozzi 13 , Antonio Sciuto 13 , Marco Migliore 14 , Alberto Patriti 15 , Marcella Lodovica Ricci 15 , Gianluca Garulli 16 , Daniele Parlanti 16 , Gabriele Vago 16 , Walter Siquini 17 , Alessandro Cardinali 17 , Stefano D'Ugo 18 , Marcello Spampinato 18 , Stefano Scabini 19 , Alessandra Aprile 19 , Domenico Soriero 19 , Marco Caricato 20 , Gabriella Teresa Capolupo 20 , Giusto Pignata 21 , Jacopo Andreuccetti 21 , Ilaria Canfora 21 , Andrea Liverani 22 , Giuseppe Lamacchia 22 , Claudia Franceschilli 22 , Roberto Campagnacci 23 , Angela Maurizi 23 , Pierluigi Marini 24 , Grazia Maria Attinà 24 , Ugo Elmore 25 , Lorenzo Gozzini 25 , Roberto Santoro 26 , Pietro Amodio 26 , Massimo Carlini 27 , Domenico Spoletini 27 , Rosa Marcellinaro 27 , Antonio Giuliani 28 , Giovanni Del Vecchio 28 , Mario Sorrentino 29 , Massimo Stefanoni 29 , Giovanni Ferrari 30 , Pietro Carnevali 30 , Gianandrea Baldazzi 31 , Diletta Cassini 31 , Alberto Di Leo 32 , Lorenzo Crepaz 32 , Augusto Verzelli 33 , Andrea Budassi 33 , Giuseppe Sica 34 , Giulia Bagaglini 34 , Davide Cavaliere 35 , Leonardo Solaini 35 , Giorgio Ercolani 35 , Gian Luca Baiocchi 36 , Sarah Molfino 36 , Marco Milone 37 , Giovanni Domenico De Palma 37 , Giovanni Ciaccio 38 , Paolo Locurto 38 , Giovanni Tebala 39 , Antonio Di Cintio 39 , Luigi Boni 40 , Elisa Cassinotti 40 , Stefano Mancini 41 , Andrea Sagnotta 41 , Mario Guerrieri 42 , Monica Ortenzi 42 , Roberto Persiani 43 , Alberto Biondi 43 , Andrea Lucchi 44 , Giulia Vitali 44 , Dario Parini 45 , Maurizio De Luca 45 , Antonino Spinelli 46 , Francesco Carrano 46 , Annalisa Maroli 46 , Michele Genna 47 , Francesca Fior 47 , Vincenzo Bottino 48 , Antonio Ferronetti 48 , Andrea Coratti 49 , Giuseppe Giuliani 49 , Roberto Benigni 49 , Andrea Muratore 50 , Patrizia Marsanic 50 , Nicoletta Sveva Pipitone Federico 50 , Maurizio Pavanello 51 , Carlo Di Marco 51 , Iacopo Graziosi 51 , Umberto Rivolta 52 , Camillo Leonardo Bertoglio 52 , Micaela Piccoli 53 , Francesca Pecchini 53 , Carlo Talarico 54 , Vincenzo Greco 54 , Alessandro Carrara 55 , Michele Motter 55 , Giuseppe Tirone 55 , Mauro Totis 56 , Nicolò Tamini 56 , Marco Braga 56 , Franco Roviello 57 , Riccardo Piagnerelli 57 , Alessandro Anastasi 58 , Giuseppe Canonico 58 , Gianluca Guercioni 59 , Simone Cicconi 59 , Giuseppe Maria Ettorre 60 , Marco Colasanti 60 , Mauro Montuori 61 , Enrico Pinotti 61 , Pierpaolo Mariani 62 , Roberta Carminati 62 , Nicolò de Manzini 63 , Edoardo Osenda 63 , Annibale Donini 64 , Luigina Graziosi 64 , Mariano Fortunato Armellino 65 , Ciro De Martino 65 , Lucio Taglietti 66 , Silvia Ruggiero 66 , Gabriele Anania 67 , Matteo Chiozza 67 , Mariantonietta Di Cosmo 68 , Daniele Zigiotto 68 , Carlo Vittorio Feo 69 , Fioralba Pindozzi 69 , Paolo Millo 70 , Manuela Grivon 70 , Corrado Pedrazzani 71 , Cristian Conti 71 , Silvio Guerriero 72 , Lorenzo Organetti 72 , Andrea Costanzi 73 , Michela Monteleone 73 , Nereo Vettoretto 74 , Emanuele Botteri 74 , Federico Marchesi 75 , Giorgio Dalmonte 75 , Graziano Longo 76 , Simone Santoni 76
Affiliations
- 1 General Surgery Unit, Sandro Pertini Hospital, ASL Roma 2, Roma, Italy.
- 2 General Surgery Unit, Università degli Studi dell'Aquila, L'Aquila, Italy. Electronic address: stefano.guadagni@univaq.it.
- 3 General Surgery Unit, Santa Maria Annunziata & Serristori Hospital, Firenze, Italy.
- 4 Department of Surgical Oncology, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
- 5 Colorectal Surgical Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale IRCCS-Italia", Napoli, Italy.
- 6 General Surgery Unit, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, VR, Italy.
- 7 Oncologic Surgery Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy.
- 8 Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.
- 9 General Surgery Unit, Università degli Studi dell'Aquila, L'Aquila, Italy.
- 10 General Surgery Unit, Santa Maria Annunziata & Serristori Hospital, Florence, Italy.
- 11 General Surgery Unit, Cardinale G. Panico Hospital, Tricase, LE, Italy.
- 12 General Surgery and IBD Unit, Careggi University Hospital, Firenze, Italy.
- 13 General Surgery Unit, ASL Napoli 2 Nord, Pozzuoli, NA, Italy.
- 14 General & Oncologic Surgery Unit, Department of Surgery, Santa Croce e Carle Hospital, Cuneo, Italy.
- 15 Department of Surgery, Marche Nord Hospital, Pesaro e Fano, PU, Italy.
- 16 General Surgery Unit, Infermi Hospital, Rimini, Italy.
- 17 General Surgery Unit, S. Lucia Hospital, Macerata, Italy.
- 18 General Surgery Unit, "V. Fazzi" Hospital, Lecce, Italy.
- 19 General & Oncologic Surgery Unit, IRCCS "San Martino" National Cancer Center, Genova, Italy.
- 20 Colorectal Surgery Unit, Policlinico Campus BioMedico, Roma, Italy.
- 21 2(nd) General Surgery Unit 2, Spedali Civili di Brescia, Italy.
- 22 General Surgery Unit, Regina Apostolorum Hospital, Albano Laziale, RM, Italy.
- 23 General Surgery Unit, "C. Urbani" Hospital, Jesi, AN, Italy.
- 24 General & Emergency Surgery Unit, San Camillo-Forlanini Hospital, Roma, Italy.
- 25 Department of Gastrointestinal Surgery Unit, San Raffaele Research Hospital and "Vita-Salute" San Raffaele University, Milano, Italy.
- 26 General Oncologic Surgery Unit, Belcolle Hospital, Viterbo, Italy.
- 27 General Surgery Unit, S. Eugenio Hospital, ASL Roma 2, Italy.
- 28 General Surgery Unit, S. Carlo Hospital, Potenza, Italy.
- 29 General Surgery Unit, Latisana-Palmanova Hospital, Friuli Centrale University (UD), Italy.
- 30 General Oncologic and Mininvasive Surgery Unit, Great Metropolitan Niguarda Hospital, Milano, Italy.
- 31 General Surgery Unit, ASST Ovest Milanese, Nuovo Ospedale di Legnano, Legnano, MI, Italy.
- 32 General and Minimally Invasive Surgery Unit, San Camillo Hospital, Trento, Italy.
- 33 General Surgery Unit, Profili Hospital, Fabriano, AN, Italy.
- 34 Minimally Invasive Surgery Unit, Policlinico Tor Vergata University Hospital, Roma, Italy.
- 35 General & Oncologic Surgery Unit, AUSL Romagna, Forlì, FC, Italy.
- 36 General Surgery Unit, Department of Clinical and Experimental Science, Department of Clinical and Experimental Sciences, University of Brescia at the Azienda Socio Sanitaria Territoriale (ASST), Cremona, Italy.
- 37 General & Endoscopic Surgery Unit, "Federico II" University, Napoli, Italy.
- 38 General Surgery Unit, S. Elia Hospital, Caltanissetta, Italy.
- 39 General Surgery Unit, S. Maria Hospital, Terni, Italy.
- 40 General Surgery Unit, Fondazione IRCCS Ca' Granda, Policlinico Maggiore Hospital, Milano, Italy.
- 41 General & Oncologic Surgery Unit, San Filippo Neri Hospital, ASL Roma 1, Italy.
- 42 Surgical Clinic, Torrette Hospital, University of Ancona, Italy.
- 43 General Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
- 44 General Surgery Unit, "Ceccarini" Hospital, Riccione, RN, Italy.
- 45 General Surgery Unit, S. Maria della Misericordia Hospital, Rovigo, Italy.
- 46 Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI) and IRCCS Humanitas Research Hospital, Rozzano, MI, Italy.
- 47 General & Bariatric Surgery Unit, University Hospital, Verona, Italy.
- 48 General & Oncologic Surgery Unit, Evangelico Betania Hospital, Napoli, Italy.
- 49 General and Emergency Surgery Unit, Misericordia Hospital, Grosseto, Italy.
- 50 General Surgery Unit, "E. Agnelli" Hospital, Pinerolo, TO, Italy.
- 51 General Surgery Unit, AULSS2 Marca Trevigiana, Conegliano Veneto, TV, Italy.
- 52 General Surgery Unit, Fornaroli Hospital, ASST Milano Ovest, Magenta, MI, Italy.
- 53 General Surgery Unit, Civil Hospital, Baggiovara, MO, Italy.
- 54 General Surgery Unit, Villa dei Gerani Hospital, Vibo Valentia, VV, Italy.
- 55 1th General Surgery Unit, S. Chiara Hospital, Trento, Italy.
- 56 Colorectal Surgery Unit, San Gerardo Hospital, ASST, Monza, Italy.
- 57 Surgical Clinic, University of Siena, Italy.
- 58 General Surgery Unit, San Giovanni di Dio Hospital, Firenze, Italy.
- 59 General Surgery Unit, "C. e G. Mazzoni" Hospital, Ascoli Piceno, Italy.
- 60 General & Transplant Surgery Unit, San Camillo-Forlanini Hospital, Roma, Italy.
- 61 General & Mininvasive Surgery Unit, S. Pietro Hospital, Ponte San Pietro, BG, Italy.
- 62 General Surgery Unit, Pesenti Fenaroli Hospital, Alzano Lombardo, BG, Italy.
- 63 Surgical Clinic, University of Trieste, Italy.
- 64 General & Emergency Surgery Unit, University of Perugia, Italy.
- 65 General & Emergency Surgery Unit, S. Giovanni di Dio e Ruggi d'Aragona Hospital, Salerno, Italy.
- 66 General Surgery Unit, ASST Valcamonica, Esine, BS, Italy.
- 67 General & Laparoscopic Surgery Unit, University Hospital, Ferrara, Italy.
- 68 General & Upper GI Surgery Unit, University Hospital, Verona, Italy.
- 69 General Surgery Unit, Delta Hospital, Lagosanto, FE, Italy.
- 70 General Surgery Unit, "U. Parini" Regional Hospital, Aosta, Italy.
- 71 General & HPB Surgery Unit, University Hospital, Verona, Italy.
- 72 General Surgery Unit, "A. Murri" Hospital, Fermo, Italy.
- 73 General Surgery Unit, S. Leopoldo Hospital, Merate, LC, Italy.
- 74 General Surgery Unit, Spedali Civili of Brescia, Montichiari, BS, Italy.
- 75 Surgical Clinic, University of Parma, Italy.
- 76 General Surgery Unit, Policlinico Casilino, Roma, Italy.
- PMID: 40902394
- DOI: 10.1016/j.ejso.2025.110379
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Enhanced recovery and survival after elective surgery for colorectal cancer - propensity score weighting analysis of 2,865 prospective patients
Marco Catarci et al.
Eur J Surg Oncol.
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doi: 10.1016/j.ejso.2025.110379.
Online ahead of print.
Authors
Collaborators
-
Italian ColoRectal Anastomotic Leakage (iCral) study group:
Paolo Ciano 1 , Michele Benedetti 1 , Leonardo Antonio Montemurro 1 , Maria Sole Mattei 1 , Elena Belloni 1 , Matteo Di Carlo 1 , Daniela Apa 1 , Marco Clementi 9 , Lorenzo Pandolfini 10 , Alessandro Falsetto 10 , Michele Simone 4 , Ugo Pace 5 , Andrea Fares Bucci 5 , Elisa Bertocchi 6 , Gaia Masini 6 , Massimo Giuseppe Viola 11 , Amedeo Altamura 11 , Francesco Rubichi 11 , Ferdinando Ficari 12 , Francesco Giudici 12 , Fabio Cianchi 12 , Felice Pirozzi 13 , Antonio Sciuto 13 , Marco Migliore 14 , Alberto Patriti 15 , Marcella Lodovica Ricci 15 , Gianluca Garulli 16 , Daniele Parlanti 16 , Gabriele Vago 16 , Walter Siquini 17 , Alessandro Cardinali 17 , Stefano D'Ugo 18 , Marcello Spampinato 18 , Stefano Scabini 19 , Alessandra Aprile 19 , Domenico Soriero 19 , Marco Caricato 20 , Gabriella Teresa Capolupo 20 , Giusto Pignata 21 , Jacopo Andreuccetti 21 , Ilaria Canfora 21 , Andrea Liverani 22 , Giuseppe Lamacchia 22 , Claudia Franceschilli 22 , Roberto Campagnacci 23 , Angela Maurizi 23 , Pierluigi Marini 24 , Grazia Maria Attinà 24 , Ugo Elmore 25 , Lorenzo Gozzini 25 , Roberto Santoro 26 , Pietro Amodio 26 , Massimo Carlini 27 , Domenico Spoletini 27 , Rosa Marcellinaro 27 , Antonio Giuliani 28 , Giovanni Del Vecchio 28 , Mario Sorrentino 29 , Massimo Stefanoni 29 , Giovanni Ferrari 30 , Pietro Carnevali 30 , Gianandrea Baldazzi 31 , Diletta Cassini 31 , Alberto Di Leo 32 , Lorenzo Crepaz 32 , Augusto Verzelli 33 , Andrea Budassi 33 , Giuseppe Sica 34 , Giulia Bagaglini 34 , Davide Cavaliere 35 , Leonardo Solaini 35 , Giorgio Ercolani 35 , Gian Luca Baiocchi 36 , Sarah Molfino 36 , Marco Milone 37 , Giovanni Domenico De Palma 37 , Giovanni Ciaccio 38 , Paolo Locurto 38 , Giovanni Tebala 39 , Antonio Di Cintio 39 , Luigi Boni 40 , Elisa Cassinotti 40 , Stefano Mancini 41 , Andrea Sagnotta 41 , Mario Guerrieri 42 , Monica Ortenzi 42 , Roberto Persiani 43 , Alberto Biondi 43 , Andrea Lucchi 44 , Giulia Vitali 44 , Dario Parini 45 , Maurizio De Luca 45 , Antonino Spinelli 46 , Francesco Carrano 46 , Annalisa Maroli 46 , Michele Genna 47 , Francesca Fior 47 , Vincenzo Bottino 48 , Antonio Ferronetti 48 , Andrea Coratti 49 , Giuseppe Giuliani 49 , Roberto Benigni 49 , Andrea Muratore 50 , Patrizia Marsanic 50 , Nicoletta Sveva Pipitone Federico 50 , Maurizio Pavanello 51 , Carlo Di Marco 51 , Iacopo Graziosi 51 , Umberto Rivolta 52 , Camillo Leonardo Bertoglio 52 , Micaela Piccoli 53 , Francesca Pecchini 53 , Carlo Talarico 54 , Vincenzo Greco 54 , Alessandro Carrara 55 , Michele Motter 55 , Giuseppe Tirone 55 , Mauro Totis 56 , Nicolò Tamini 56 , Marco Braga 56 , Franco Roviello 57 , Riccardo Piagnerelli 57 , Alessandro Anastasi 58 , Giuseppe Canonico 58 , Gianluca Guercioni 59 , Simone Cicconi 59 , Giuseppe Maria Ettorre 60 , Marco Colasanti 60 , Mauro Montuori 61 , Enrico Pinotti 61 , Pierpaolo Mariani 62 , Roberta Carminati 62 , Nicolò de Manzini 63 , Edoardo Osenda 63 , Annibale Donini 64 , Luigina Graziosi 64 , Mariano Fortunato Armellino 65 , Ciro De Martino 65 , Lucio Taglietti 66 , Silvia Ruggiero 66 , Gabriele Anania 67 , Matteo Chiozza 67 , Mariantonietta Di Cosmo 68 , Daniele Zigiotto 68 , Carlo Vittorio Feo 69 , Fioralba Pindozzi 69 , Paolo Millo 70 , Manuela Grivon 70 , Corrado Pedrazzani 71 , Cristian Conti 71 , Silvio Guerriero 72 , Lorenzo Organetti 72 , Andrea Costanzi 73 , Michela Monteleone 73 , Nereo Vettoretto 74 , Emanuele Botteri 74 , Federico Marchesi 75 , Giorgio Dalmonte 75 , Graziano Longo 76 , Simone Santoni 76
Affiliations
- 1 General Surgery Unit, Sandro Pertini Hospital, ASL Roma 2, Roma, Italy.
- 2 General Surgery Unit, Università degli Studi dell'Aquila, L'Aquila, Italy. Electronic address: stefano.guadagni@univaq.it.
- 3 General Surgery Unit, Santa Maria Annunziata & Serristori Hospital, Firenze, Italy.
- 4 Department of Surgical Oncology, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
- 5 Colorectal Surgical Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale IRCCS-Italia", Napoli, Italy.
- 6 General Surgery Unit, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, VR, Italy.
- 7 Oncologic Surgery Unit, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy.
- 8 Department of Biotechnological and Applied Clinical Sciences, Università degli Studi dell'Aquila, L'Aquila, Italy.
- 9 General Surgery Unit, Università degli Studi dell'Aquila, L'Aquila, Italy.
- 10 General Surgery Unit, Santa Maria Annunziata & Serristori Hospital, Florence, Italy.
- 11 General Surgery Unit, Cardinale G. Panico Hospital, Tricase, LE, Italy.
- 12 General Surgery and IBD Unit, Careggi University Hospital, Firenze, Italy.
- 13 General Surgery Unit, ASL Napoli 2 Nord, Pozzuoli, NA, Italy.
- 14 General & Oncologic Surgery Unit, Department of Surgery, Santa Croce e Carle Hospital, Cuneo, Italy.
- 15 Department of Surgery, Marche Nord Hospital, Pesaro e Fano, PU, Italy.
- 16 General Surgery Unit, Infermi Hospital, Rimini, Italy.
- 17 General Surgery Unit, S. Lucia Hospital, Macerata, Italy.
- 18 General Surgery Unit, "V. Fazzi" Hospital, Lecce, Italy.
- 19 General & Oncologic Surgery Unit, IRCCS "San Martino" National Cancer Center, Genova, Italy.
- 20 Colorectal Surgery Unit, Policlinico Campus BioMedico, Roma, Italy.
- 21 2(nd) General Surgery Unit 2, Spedali Civili di Brescia, Italy.
- 22 General Surgery Unit, Regina Apostolorum Hospital, Albano Laziale, RM, Italy.
- 23 General Surgery Unit, "C. Urbani" Hospital, Jesi, AN, Italy.
- 24 General & Emergency Surgery Unit, San Camillo-Forlanini Hospital, Roma, Italy.
- 25 Department of Gastrointestinal Surgery Unit, San Raffaele Research Hospital and "Vita-Salute" San Raffaele University, Milano, Italy.
- 26 General Oncologic Surgery Unit, Belcolle Hospital, Viterbo, Italy.
- 27 General Surgery Unit, S. Eugenio Hospital, ASL Roma 2, Italy.
- 28 General Surgery Unit, S. Carlo Hospital, Potenza, Italy.
- 29 General Surgery Unit, Latisana-Palmanova Hospital, Friuli Centrale University (UD), Italy.
- 30 General Oncologic and Mininvasive Surgery Unit, Great Metropolitan Niguarda Hospital, Milano, Italy.
- 31 General Surgery Unit, ASST Ovest Milanese, Nuovo Ospedale di Legnano, Legnano, MI, Italy.
- 32 General and Minimally Invasive Surgery Unit, San Camillo Hospital, Trento, Italy.
- 33 General Surgery Unit, Profili Hospital, Fabriano, AN, Italy.
- 34 Minimally Invasive Surgery Unit, Policlinico Tor Vergata University Hospital, Roma, Italy.
- 35 General & Oncologic Surgery Unit, AUSL Romagna, Forlì, FC, Italy.
- 36 General Surgery Unit, Department of Clinical and Experimental Science, Department of Clinical and Experimental Sciences, University of Brescia at the Azienda Socio Sanitaria Territoriale (ASST), Cremona, Italy.
- 37 General & Endoscopic Surgery Unit, "Federico II" University, Napoli, Italy.
- 38 General Surgery Unit, S. Elia Hospital, Caltanissetta, Italy.
- 39 General Surgery Unit, S. Maria Hospital, Terni, Italy.
- 40 General Surgery Unit, Fondazione IRCCS Ca' Granda, Policlinico Maggiore Hospital, Milano, Italy.
- 41 General & Oncologic Surgery Unit, San Filippo Neri Hospital, ASL Roma 1, Italy.
- 42 Surgical Clinic, Torrette Hospital, University of Ancona, Italy.
- 43 General Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
- 44 General Surgery Unit, "Ceccarini" Hospital, Riccione, RN, Italy.
- 45 General Surgery Unit, S. Maria della Misericordia Hospital, Rovigo, Italy.
- 46 Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI) and IRCCS Humanitas Research Hospital, Rozzano, MI, Italy.
- 47 General & Bariatric Surgery Unit, University Hospital, Verona, Italy.
- 48 General & Oncologic Surgery Unit, Evangelico Betania Hospital, Napoli, Italy.
- 49 General and Emergency Surgery Unit, Misericordia Hospital, Grosseto, Italy.
- 50 General Surgery Unit, "E. Agnelli" Hospital, Pinerolo, TO, Italy.
- 51 General Surgery Unit, AULSS2 Marca Trevigiana, Conegliano Veneto, TV, Italy.
- 52 General Surgery Unit, Fornaroli Hospital, ASST Milano Ovest, Magenta, MI, Italy.
- 53 General Surgery Unit, Civil Hospital, Baggiovara, MO, Italy.
- 54 General Surgery Unit, Villa dei Gerani Hospital, Vibo Valentia, VV, Italy.
- 55 1th General Surgery Unit, S. Chiara Hospital, Trento, Italy.
- 56 Colorectal Surgery Unit, San Gerardo Hospital, ASST, Monza, Italy.
- 57 Surgical Clinic, University of Siena, Italy.
- 58 General Surgery Unit, San Giovanni di Dio Hospital, Firenze, Italy.
- 59 General Surgery Unit, "C. e G. Mazzoni" Hospital, Ascoli Piceno, Italy.
- 60 General & Transplant Surgery Unit, San Camillo-Forlanini Hospital, Roma, Italy.
- 61 General & Mininvasive Surgery Unit, S. Pietro Hospital, Ponte San Pietro, BG, Italy.
- 62 General Surgery Unit, Pesenti Fenaroli Hospital, Alzano Lombardo, BG, Italy.
- 63 Surgical Clinic, University of Trieste, Italy.
- 64 General & Emergency Surgery Unit, University of Perugia, Italy.
- 65 General & Emergency Surgery Unit, S. Giovanni di Dio e Ruggi d'Aragona Hospital, Salerno, Italy.
- 66 General Surgery Unit, ASST Valcamonica, Esine, BS, Italy.
- 67 General & Laparoscopic Surgery Unit, University Hospital, Ferrara, Italy.
- 68 General & Upper GI Surgery Unit, University Hospital, Verona, Italy.
- 69 General Surgery Unit, Delta Hospital, Lagosanto, FE, Italy.
- 70 General Surgery Unit, "U. Parini" Regional Hospital, Aosta, Italy.
- 71 General & HPB Surgery Unit, University Hospital, Verona, Italy.
- 72 General Surgery Unit, "A. Murri" Hospital, Fermo, Italy.
- 73 General Surgery Unit, S. Leopoldo Hospital, Merate, LC, Italy.
- 74 General Surgery Unit, Spedali Civili of Brescia, Montichiari, BS, Italy.
- 75 Surgical Clinic, University of Parma, Italy.
- 76 General Surgery Unit, Policlinico Casilino, Roma, Italy.
- PMID: 40902394
- DOI: 10.1016/j.ejso.2025.110379
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Abstract
Background: The impact of enhanced recovery pathway (ERP) on survival after colorectal cancer surgery (CCS) remains controversial.
Materials and methods: A total of 2865 adults enrolled in a multicenter cohort study (iCral3 study) after CCS were followed up. The percentage adherence to the ERP was recorded, and the patients were grouped according to their quartiles. Other patient-, center-, disease-, and treatment-related factors were considered in a machine learning generalized boosted model (GBM) to estimate the 22 covariates propensity score weights for the binary comparisons between the reference treatment (1st quartile, ERP adherence rates <57.7 %) and the other treatment arms (2nd, 3rd, and 4th quartile). The primary endpoint was overall survival (OS). A GBM-weighted Cox model balanced on the same covariates was used to estimate the hazard ratio (HR) and 95 % confidence interval (95 %CI).
Results: Patients in the 4th quartile (ERP adherence rates ≥80.8 %) showed a significant lower risk of death from any cause (HR, 0.69; 95 %CI 0.49-0.96; p = 0.026).
Conclusions: High adherence to ERP was associated to a significant impact on long-term overall survival, supporting the efforts towards proper ERP implementation after CCS.
Keywords: Colorectal neoplasms; Enhanced recovery after surgery; Survival.
Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of competing interest None.
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