Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Dec;103(12):781-889.
doi: 10.1111/avj.70003. Epub 2025 Sep 3.

Antimicrobial prescribing guidelines for horses in Australia

Affiliations
Review

Antimicrobial prescribing guidelines for horses in Australia

L Hardefeldt et al. Aust Vet J. 2025 Dec.

Abstract

The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses. While antimicrobials are commonly used to treat equine infections, complications with therapy are also relatively common. Antimicrobial-associated diarrhoea, immune-mediated diseases, and nephrotoxicity have been reported as sequelae of antimicrobial therapy in equine practice. This does not indicate that clinicians should avoid using these drugs, only that knowledge of the potential for adverse effects is critical when deciding on the most appropriate antimicrobial to use and can assist in avoiding serious side effects, wherever possible, or at least in detecting and responding to them early. These guidelines comprehensively outline key features of infectious diseases in horses, diagnostic testing, and therapeutic guidelines for use in treating horses in Australia.

PubMed Disclaimer

References

    1. Southwood LL. Surgical antimicrobial prophylaxis: current standards of care. Equine Vet Educ 2023;35(11):607–616.
    1. Australian Commission on Safety and Quality in Health Care. Approaches to surgical site infection surveillance. Sydney, ACSQHC, 2017.
    1. Uboh CE, Soma LR, Luo Y et al. Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses. Am J Vet Res 2000;61(7):811–815.
    1. Hubbell JA, Muir WW, Robertson JT et al. Cardiovascular effects of intravenous sodium penicillin, sodium cefazolin, and sodium citrate in awake and anesthetized horses. Vet Surg 1987;16(3):245–250.
    1. Henderson ARP, Valverde A, Marchiori J et al. Effect of rapid and slow intravenous injection of sodium penicillin on arterial blood pressure in isoflurane‐anesthetized horses during surgery. Vet Anaesth Analg 2025;52(2):200–207.

MeSH terms

Substances

LinkOut - more resources