British Society for Haematology updated guidelines for the diagnosis and management of tumour lysis syndrome in adults and children with haematological malignancies: A focus on patient safety

Y L Tracey Chan¹, Dima El-Sharkawi², Paras Shah², Dimitrios Chanouzas¹, David O'Connor^{3

4}, Stephen D Marks^{4

5

6}, Gail Jones⁷; BSH Committee

Affiliations

¹ University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
² The Royal Marsden NHS Foundation Trust, London, UK.
³ Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
⁴ University College London Great Ormond Street Institute of Child Health, London, UK.
⁵ Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
⁶ NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.
⁷ Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Y L Tracey Chan et al. Br J Haematol. 2025 Oct.

. 2025 Oct;207(4):1248-1258.

doi: 10.1111/bjh.70092. Epub 2025 Sep 3.

Y L Tracey Chan¹, Dima El-Sharkawi², Paras Shah², Dimitrios Chanouzas¹, David O'Connor^{3

4}, Stephen D Marks^{4

5

6}, Gail Jones⁷; BSH Committee

¹ University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
² The Royal Marsden NHS Foundation Trust, London, UK.
³ Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
⁴ University College London Great Ormond Street Institute of Child Health, London, UK.
⁵ Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
⁶ NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.
⁷ Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

No abstract available

Keywords: clinical haematology; haematological malignancy; therapy.

References

1. Jones GL, Will A, Jackson GH, Webb NJA, Rule S, the British Committee for Standards in Haematology. Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology. Br J Haematol. 2015;169(5):661–671.
1. Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127:3–11.
1. Montesinos P, Lorenzo I, Martín G, Sanz J, Luz Pérez‐Sirvent M, Martínez D, et al. Tumor lysis syndrome in patients with acute myeloid leukemia: identification of risk factors and development of a predictive model. Haematologica. 2008;93(1):67–74.
1. Seidemann K, Meyer U, Jansen P, Yakisan E, Rieske K, Führer M, et al. Impaired renal function and tumor lysis syndrome in pediatric patients with non‐Hodgkin's lymphoma and B‐ALL. Observations from the BFM‐trials. Klin Padiatr. 1998;210(4):279–284.
1. Mato AR, Riccio BE, Qin L, Heitjan DF, Carroll M, Loren A, et al. A predictive model for the detection of tumor lysis syndrome during AML induction therapy. Leuk Lymphoma. 2006;47(5):877–883.