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. 2025 Nov;15(11):3089-3108.
doi: 10.1007/s13555-025-01515-x. Epub 2025 Sep 4.

Strategies for Optimal Use of Biological Therapies in Managing Psoriasis: Focus on Secukinumab

Anna Balato  1 , Martina Burlando  2 , Anna Campanati  3 , Antonio Costanzo  4   5 , Andrea Chiricozzi  6   7 , Paolo Gisondi  8 , Piergiorgio Malagoli  9 , Giuseppe Micali  10 ; Psoriasis Working Group
Collaborators, Affiliations

Strategies for Optimal Use of Biological Therapies in Managing Psoriasis: Focus on Secukinumab

Anna Balato et al. Dermatol Ther (Heidelb). 2025 Nov.

Abstract

Introduction: Psoriasis (PsO) is a common inflammatory dermatological condition with a substantial negative impact on patient quality of life. Several biological agents are available for the treatment of PsO, and clinicians and patients must consider various factors when deciding on the most appropriate biological agent.

Methods: Here, we report a set of consensus statements developed by an Italian PsO advisory board on use of the anti-interleukin-17A biological secukinumab in routine clinical practice.

Results: The statements were developed under three main topics, the first of which was "characteristics of secukinumab and criteria for patient selection to achieve long-term benefits". This statement helps to identify patients most likely to benefit from secukinumab, including biological-naïve patients with moderate PsO; patients with PsO involving sensitive sites; patients in whom biosimilar anti-tumour necrosis factor-alpha treatment has proved ineffective; patients at high risk of developing psoriatic arthritis; lean or normal-weight patients; patients with active disease receiving conventional disease-modifying antirheumatic drugs; and patients with comorbidities, including cardiovascular disease. Under the second topic, "strategies to maintain secukinumab effectiveness in the long term", the advisors highlighted the importance of patient support to promote adherence; weight control; understanding that PsO can worsen for reasons unrelated to treatment; and understanding that appropriate treatment should depend on the severity of any disease worsening. The third topic, "strategies for patient support to promote adherence to therapy", noted the importance of patient education, accurate disease assessments and treatment tailoring.

Conclusion: These consensus statements will help guide dermatologists in the selection of patients with PsO for whom secukinumab is the most appropriate treatment in real-world clinical practice in Italy.

Keywords: Biologicals; Consensus statements; Expert opinion; Psoriasis; Secukinumab.

Plain language summary

Psoriasis is a common disease that causes dry, discoloured patches of skin that can cover large areas of the body; many people also develop nail changes. The skin can become very itchy, crack or bleed, and patients may have difficulty with basic everyday tasks. Biological agents that treat psoriasis work by targeting and blocking only the overactive part of the body’s immune system that causes psoriasis and its symptoms. Therefore, biological agents are less likely than other psoriasis medicines to cause problems with the liver, kidneys and other organs. Biologicals are an important treatment option for people with moderate-to-severe psoriasis, especially as many people’s symptoms fail to respond to other treatments. None of the currently available biologicals is better than its competitors for all patients with psoriasis, so it is difficult for clinicians to choose which biological is best for an individual patient. However, one biological, secukinumab, has been available for almost 10 years, so there is long-term evidence supporting its safety. This is an advantage for secukinumab over the newer biologicals also used to treat psoriasis. An Italian group of experts and specialists with experience in treating patients with psoriasis recently discussed the safety, manageability and effectiveness of secukinumab in psoriasis. The experts produced a set of recommendations, or ‘consensus statements’, to guide clinicians on selecting patients with psoriasis who are best suited for secukinumab treatment in real-world clinical practice in Italy. This article presents the consensus statements from the Italian expert group.

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Conflict of interest statement

Declarations. Conflict of Interest: Anna Balato has served as consultant and/or has received fees from: AbbVie, Almirall, Amgen, BMS, Boehringer Ingelheim, Eli Lilly, LEO Pharma, Janssen, Sanofi, and UCB. Anna Campanati has served as a speaker or board member for AbbVie, Almirall, Galderma, Celgene, LEO Pharma, Eli Lilly, Merck Sharp & Dohme, Novartis, Pfizer, and UCB; and is a current Editorial Board member for Dermatology and Therapy. Antonio Costanzo has served as a speaker or board member for AbbVie, Amgen, Galderma, Celgene, LEO Pharma, Eli Lilly, Boehringer Ingelheim, Novartis, Pfizer, and UCB. Paolo Gisondi is a current Editorial Board member for Dermatology and Therapy. Martina Burlando, Andrea Chiricozzi, Piergiorgio Malagoli, and Giuseppe Micali declare that they have no competing interests. Ethical Approval: This article is based on previously conducted studies and does not contain any new studies (with human participants or animals) performed by any of the authors. Ethical approval was not required. All dermatologists signed a contract when they agreed to participate in the Psoriasis Working Group; the contract outlined the objectives of the advisory boards and stated that the voting results would be published. Dermatologists’ data were protected by electronic storage with advanced security technologies and periodic backups to protect data integrity and confidentiality. The study sponsor (Novartis) selected the advisory board participants based on their clinical experience in managing patients with psoriasis but had no subsequent input into the project.

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