Analysis of skin immune cells in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

Allison Clatch¹, Jason A Trubiano²; AUS-SCAR Consortium; Fiona James³, Effie Mouhtouris³, Irvin Ng⁴, Johannes S Kern⁵, Abby Douglas⁶, Michelle S Y Goh⁷, Laura Scardamaglia⁸, Graham Starkey⁹, Rohit D'Costa¹⁰, Varun Sharma¹¹, Aly Fayed¹¹, Laura K Mackay¹², Susan N Christo¹, Claire L Gordon¹³

Collaborators, Affiliations

Collaborators

Affiliations

¹ Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
² Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. Electronic address: Jason.trubiano@austin.org.au.
³ Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia.
⁴ Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia.
⁵ Department of Dermatology, Alfred Health, Melbourne, Victoria 3004, Australia; School of Translational Medicine, Monash University, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, 3000, Australia.
⁶ Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, Victoria, 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, 3000, Australia.
⁷ Department of Dermatology, Alfred Health, Melbourne, Victoria 3004, Australia; School of Translational Medicine, Monash University, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, 3000, Australia; Department of Dermatology, Austin Health, Heidelberg, Victoria, 3084, Australia; Department of Dermatology, Melbourne Health, Melbourne, Victoria, 3000, Australia.
⁸ Department of Medicine, University of Melbourne, Melbourne, Victoria, 3000, Australia; Department of Dermatology, Melbourne Health, Melbourne, Victoria, 3000, Australia; Department of Dermatology, Western Health, Footscray, 3011, Australia.
⁹ Victorian and Tasmanian Organ Retrieval Service, Austin Health, Melbourne, VIC, Australia; Australian Centre for Transplantation Excellence and Research, Austin Health, Melbourne, VIC, Australia; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, VIC, Australia.
¹⁰ DonateLife Victoria, Carlton, Victoria; Department of Intensive Care Medicine, Melbourne Health, Melbourne, VIC, Australia.
¹¹ Victorian and Tasmanian Organ Retrieval Service, Austin Health, Melbourne, VIC, Australia; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, VIC, Australia.
¹² Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. Electronic address: lkmackay@unimelb.edu.au.
¹³ Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; North Eastern Public Health Unit, Austin Health, Heidelberg, Victoria, 3084, Australia.

PMID: 40907602
DOI: 10.1016/j.jid.2025.08.027

Analysis of skin immune cells in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

Allison Clatch et al. J Invest Dermatol. 2025.

. 2025 Sep 2:S0022-202X(25)02401-7.

doi: 10.1016/j.jid.2025.08.027. Online ahead of print.

Authors

Collaborators

Affiliations

¹ Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.
² Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. Electronic address: Jason.trubiano@austin.org.au.
³ Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia.
⁴ Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia.
⁵ Department of Dermatology, Alfred Health, Melbourne, Victoria 3004, Australia; School of Translational Medicine, Monash University, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, 3000, Australia.
⁶ Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, Victoria, 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, 3000, Australia.
⁷ Department of Dermatology, Alfred Health, Melbourne, Victoria 3004, Australia; School of Translational Medicine, Monash University, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, 3000, Australia; Department of Dermatology, Austin Health, Heidelberg, Victoria, 3084, Australia; Department of Dermatology, Melbourne Health, Melbourne, Victoria, 3000, Australia.
⁸ Department of Medicine, University of Melbourne, Melbourne, Victoria, 3000, Australia; Department of Dermatology, Melbourne Health, Melbourne, Victoria, 3000, Australia; Department of Dermatology, Western Health, Footscray, 3011, Australia.
⁹ Victorian and Tasmanian Organ Retrieval Service, Austin Health, Melbourne, VIC, Australia; Australian Centre for Transplantation Excellence and Research, Austin Health, Melbourne, VIC, Australia; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, VIC, Australia.
¹⁰ DonateLife Victoria, Carlton, Victoria; Department of Intensive Care Medicine, Melbourne Health, Melbourne, VIC, Australia.
¹¹ Victorian and Tasmanian Organ Retrieval Service, Austin Health, Melbourne, VIC, Australia; Department of Surgery, The University of Melbourne, Austin Health, Melbourne, VIC, Australia.
¹² Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. Electronic address: lkmackay@unimelb.edu.au.
¹³ Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia; Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, Victoria, 3084, Australia; North Eastern Public Health Unit, Austin Health, Heidelberg, Victoria, 3084, Australia.

PMID: 40907602
DOI: 10.1016/j.jid.2025.08.027

Abstract

Examination of the immune content in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) lesions reveals the putative role of skin-localised cytotoxic CD8⁺ T cells in disease pathogenesis.

Keywords: Drug hypersensitivity reaction; Epidermal necrolysis; Severe cutaneous adverse reactions (SCARs); Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN); Tissue-resident memory T cells.

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Analysis of skin immune cells in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

Collaborators

Affiliations

Analysis of skin immune cells in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

Authors

Collaborators

Affiliations

Abstract

LinkOut - more resources

Full Text Sources

Research Materials