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. 2025 Sep 4.
doi: 10.1038/s41388-025-03557-z. Online ahead of print.

TRIM29 promotes bladder cancer invasion by regulating the intermediate filament network and focal adhesion

Yin Wang  1 , Nicole A Jerome  1 , Alan J Kelleher  1 , Marian L Henderson  1 , Mark L Day  2 , Pierre A Coulombe  3   4 , Phillip L Palmbos  5
Affiliations

TRIM29 promotes bladder cancer invasion by regulating the intermediate filament network and focal adhesion

Yin Wang et al. Oncogene. .

Abstract

Bladder cancer is a common malignancy whose lethality is determined by invasive potential. We have previously shown that TRIM29, also known as ATDC, is transcriptionally regulated by TP63 in basal bladder cancers where it promotes invasive progression and metastasis, but the molecular events which promote invasion and metastasis downstream of TRIM29 remained poorly understood. Here we identify stimulation of bladder cancer migration as the specific role of TRIM29 during invasion. We show that TRIM29 physically interacts with K14+ intermediate filaments which, in turn, regulates focal adhesion stability. Further, we find that both K14 and the focal adhesion protein, ZYX are required for bladder cancer migration and invasion. Taken together, these results establish a role for TRIM29 in the regulation of cytoskeleton and focal adhesions during invasion and identify a pathway with therapeutic potential.

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Conflict of interest statement

Competing interests: The authors declare no competing interests. Ethics approval: All experimental methods were performed in accordance with the relevant guidelines and regulations. No human or animal subjects were used in this study.

Update of

References

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