Anti-AK5 limbic encephalitis in a patient with pleural mesothelioma

Giulia Sofia Cereda^{1

2}, Antonio Farina^{1

3}, Nolwenn Billet^{1

3}, Macarena Villagrán-García^{1

3}, Anne-Laurie Pinto^{1

3}, Marie Benaiteau^{1

3}, Dorine Templement-Grangerat⁴, Isabelle Treilleux⁵, David Meyronet⁶, David Laville⁷, Géraldine Picard^{1

3}, Virginie Desestret^{1

3}, Jérôme Honnorat^{8

9}

Affiliations

¹ French Reference Centre On Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 59 Bd Pinel, Bron Cedex, 69677, Lyon, France.
² Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
³ MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1, 69008, Lyon, France.
⁴ Respiratory Medicine Department, Centre Hospitalier Annecy Genevois (CHANGE), Annecy, France.
⁵ Department of Biopathology, Centre Leon Berard, Lyon, France.
⁶ Department of Medical Biology and Pathological Anatomy, Hospices Civils de Lyon, 69777, Bron, France.
⁷ Department of Pathology, Hospices Civils de Lyon, East Hospital Group, Bron, France.
⁸ French Reference Centre On Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 59 Bd Pinel, Bron Cedex, 69677, Lyon, France. jerome.honnorat@chu-lyon.fr.
⁹ MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1, 69008, Lyon, France. jerome.honnorat@chu-lyon.fr.

Giulia Sofia Cereda et al. J Neurol. 2025.

. 2025 Sep 4;272(9):610.

doi: 10.1007/s00415-025-13340-5.

¹ French Reference Centre On Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 59 Bd Pinel, Bron Cedex, 69677, Lyon, France.
² Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
³ MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1, 69008, Lyon, France.
⁴ Respiratory Medicine Department, Centre Hospitalier Annecy Genevois (CHANGE), Annecy, France.
⁵ Department of Biopathology, Centre Leon Berard, Lyon, France.
⁶ Department of Medical Biology and Pathological Anatomy, Hospices Civils de Lyon, 69777, Bron, France.
⁷ Department of Pathology, Hospices Civils de Lyon, East Hospital Group, Bron, France.
⁸ French Reference Centre On Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 59 Bd Pinel, Bron Cedex, 69677, Lyon, France. jerome.honnorat@chu-lyon.fr.
⁹ MeLiS-UCBL-CNRS UMR 5284. INSERM U1314, Université Claude Bernard Lyon 1, 69008, Lyon, France. jerome.honnorat@chu-lyon.fr.

No abstract available

Conflict of interest statement

Declarations. Conflicts of interest: The authors report no competing interests.

1. Muñiz-Castrillo S, Hedou JJ, Ambati A, Jones D, Vogrig A, Pinto AL et al (2021) Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis. Brain J Neurol 144(9):2709–2721 - DOI
1. McKeon-Makki I, McKeon A, Yang B, Pittock SJ, Lopez-Chiriboga S, Komorowski L et al (2022) Adenylate kinase 5 (AK5) autoimmune encephalitis: Clinical presentations and outcomes in three new patients. J Neuroimmunol 15(367):577861 - DOI
1. Do LD, Chanson E, Desestret V, Joubert B, Ducray F, Brugière S et al (2017) Characteristics in limbic encephalitis with anti-adenylate kinase 5 autoantibodies. Neurology 88(6):514–524 - DOI - PubMed
1. Sigma-Aldrich [Internet]. [cited 2025 Jun 4]. Available from: https://www.sigmaaldrich.com/IT/it/specification-sheet/SIGMA/HPA057255
1. Darnell RB, Posner JB (2003) Paraneoplastic syndromes involving the nervous system. N Engl J Med 349(16):1543–1554 - DOI - PubMed