Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep 4.
doi: 10.1007/s12094-025-04047-0. Online ahead of print.

Management of late toxicities and specific follow-up needs of adolescent and young adult cancer survivors: recommendations from scientific societies in Spain

Alejandro Pérez Fidalgo  1   2 , Pilar Alonso  3 , Maitane Andión  4 , Adela Cañete  5 , Erica Collado  6 , Carmen Garrido Colino  7 , José Gómez Codina  8 , Xavier Díaz Carrasco  9 , Ramón García Sanz  10 , Sergio Hernández Expósito  11 , Teresa Lopez-Fernandez  12 , Gabriela Medin  13 , Antonio Molinés  14 , Alberto Moreno Vega  15 , Mónica Ramos  16 , Iñigo San Miguel  17 , Joaquín Sánchez García  18 , Fátima Santolaya  19
Affiliations

Management of late toxicities and specific follow-up needs of adolescent and young adult cancer survivors: recommendations from scientific societies in Spain

Alejandro Pérez Fidalgo et al. Clin Transl Oncol. .

Abstract

Adolescent and young adult cancer survivors (AYACS) represent a specific cancer patient population with unique chronic health issues difficult to identify in early, reversible phases with standard monitoring protocols. This review, conducted by a group of Spanish experts, provides recommendations for managing AYACS, focusing on key areas, such as cardiac toxicities, neurotoxicity and neurocognitive disorders, metabolic syndrome, secondary primary malignancies, bone toxicities, sexuality and fertility, psychosocial aspects, and other treatment-related toxicities.

Keywords: Adolescent; Cancer; Recommendations; Survivors; Toxicity; Young adult.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: Alejandro Pérez Fidalgo reports Advisory Board, Speaker, Grant-Non-financial Support from Astrazeneca, GSK; Advisory Board, Speaker, Grant from Pharmamar; Advisory Board, Speaker from PharmaAnd, Deciphera and MSD; Advisory Board from Regeneron, Daichii Sankyo and Karyopharm. Adela Cañete reports grants from Norgine and Astra Zeneca; advisory board member for Norgine Spain and Recordati. José Gómez Codina reports Advisory Board from Ferrer, Roche, Astra Zeneca, Pfizer, MSD, Bristol-MS, Takeda, Accord, Casen-Recordati, Kite-Gilead, Ferrer; participation in medical meetings organised by Ferrer, Roche, Astra Zeneca, Pfizer, MSD, Bristol-MS, Takeda, Accord, Casen-Recordati, Bayer, Janssen, Kite-Gilead. Alberto Moreno Vega reports speaker invited from Novartis. Teresa López-Fernandez Speaker fees and advisory honoraria from Philips, Myocardial solutions, Janssen-Cilag, Astra Zeneca, Accord, Pfizer, Lilly not related with this work. Pilar Alonso, Maitane Andión, Erica Collado, Xavier Díaz Carrasco, Ramón García Sanz, Carmen Garrido Colino, Sergio Hernández Expósito, Gabriela Medin, Antonio Molinés, Iñigo San Miguel, Joaquín Sánchez García and Fátima Santolaya declare that they have no conflict of interest in relation to this article. Ethical approval: The manuscript does not contain clinical studies or patient data.

References

    1. Report of the Adolescent and Young Adult Oncology Progress Review Group. Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults with Cancer. 2006. https://www.cancer.gov/types/aya/research/ayao-august-2006.pdf
    1. Trama A, Stark D, Bozovic-Spasojevic I, Gaspar N, Peccatori F, Toss A, et al. Cancer burden in adolescents and young adults in Europe. ESMO Open. 2023;8:100744. https://doi.org/10.1016/j.esmoop.2022.100744 . - DOI - PubMed - PMC
    1. Miller KD, Fidler-Benaoudia M, Keegan TH, Hipp HS, Jemal A, Siegel RL. Cancer statistics for adolescents and young adults, 2020. CA Cancer J Clin. 2020;70:443–59. https://doi.org/10.3322/caac.21637 . - DOI - PubMed
    1. Marcucci G, Beltrami G, Tamburini A, Body JJ, Confavreux CB, Hadji P, et al. Bone health in childhood cancer: review of the literature and recommendations for the management of bone health in childhood cancer survivors. Ann Oncol. 2019;30:908–20. https://doi.org/10.1093/annonc/mdz120 . - DOI - PubMed
    1. Sociedad Española de Oncología Médica. [Cancer survivors in Spain: current situation Spanish Society of Medical Oncology (SEOM). SEOM monograph on long cancer survivors, 1st part]. 2013. https://www.seom.org/seomcms/images/stories/recursos/PLAN_INTEGRAL_LARGO...

LinkOut - more resources