Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Aug 25;4(1):e000931.
doi: 10.1136/bmjonc-2025-000931. eCollection 2025.

Inferior control arms in oncology trials in LMICs: contextualised or compromised?

Laure-Anne Teuwen  1 , Bishal Gyawali  2
Affiliations
Editorial

Inferior control arms in oncology trials in LMICs: contextualised or compromised?

Laure-Anne Teuwen et al. BMJ Oncol. .
No abstract available

Keywords: Clinical Trial; Medical oncology.

PubMed Disclaimer

Conflict of interest statement

LAT has received honoraria from AstraZeneca, unrelated to the manuscript. BG has received consulting fees from Vivio Health, unrelated to the manuscript.

Comment on

References

    1. Hilal T, Sonbol MB, Prasad V. Analysis of Control Arm Quality in Randomized Clinical Trials Leading to Anticancer Drug Approval by the US Food and Drug Administration. JAMA Oncol. 2019;5:887–92. doi: 10.1001/jamaoncol.2019.0167. - DOI - PMC - PubMed
    1. Rossi A, Aimar G, Audisio M, et al. Analysis of the adequacy of control arms in oncology randomised clinical trials published between 2017 and 2021: a meta-research study. Eur J Cancer. 2023;189:112920. doi: 10.1016/j.ejca.2023.05.008. - DOI - PubMed
    1. Gyawali B, de Vries EGE, Dafni U, et al. Biases in study design, implementation, and data analysis that distort the appraisal of clinical benefit and ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS) scoring. ESMO Open. 2021;6:100117. doi: 10.1016/j.esmoop.2021.100117. - DOI - PMC - PubMed
    1. Gyawali B, Eisenhauer EA, van der Graaf W, et al. Common Sense Oncology principles for the design, analysis, and reporting of phase 3 randomised clinical trials. Lancet Oncol. 2025;26:e80–9. doi: 10.1016/S1470-2045(24)00451-0. - DOI - PubMed
    1. World Medical Association . World Med Assoc; 2024. [25-Jul-2025]. WMA declaration of helsinki − ethical principles for medical research involving human subjects.https://www.wma.net/policies-post/wma-declaration-of-helsinki/ Available. Accessed. - PubMed

LinkOut - more resources