Effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo
- PMID: 40910
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Effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo
Int J Fertil.
1979.
Abstract
Indomethacin decreased Prostaglandin F 2 alpha levels in the ovaries of marmoset monkeys which were treated with PMS/HCG. The production of estradiol and progesterone, however, was unaffected by the blockade in prostaglandin synthesis. The number of ovulations following PMS/HCG treatment was significantly reduced by indomethacin treatment. These observations suggest that prostaglandins are required for follicular rupture but not for progesterone and estradiol production by the ovary.
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