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. 1979;24(2):142-4.

Effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo

I Barbosa, H Maia Jr, T Lopes, M G Elder, E M Coutinho
  • PMID: 40910

Effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo

I Barbosa et al. Int J Fertil. 1979.

Abstract

Indomethacin decreased Prostaglandin F 2 alpha levels in the ovaries of marmoset monkeys which were treated with PMS/HCG. The production of estradiol and progesterone, however, was unaffected by the blockade in prostaglandin synthesis. The number of ovulations following PMS/HCG treatment was significantly reduced by indomethacin treatment. These observations suggest that prostaglandins are required for follicular rupture but not for progesterone and estradiol production by the ovary.

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