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. 2025 Aug 20;50(3):96-101.
doi: 10.1584/jpestics.J25-02.

Development of the insecticide oxazosulfyl

Mai Ito  1 , Yoshihiko Nokura  1 , Masaki Takahashi  1 , Masashi Kamezaki  1 , Emiko Sakamoto  1 , Shinya Nishimura  1
Affiliations

Development of the insecticide oxazosulfyl

Mai Ito et al. J Pestic Sci. .

Abstract

Oxazosulfyl, a novel insecticide originally discovered and developed by Sumitomo Chemical Co., Ltd., belongs to a new chemical class, the sulfyl group, structurally characterized by its ethylsulfonyl moiety. It exhibits excellent control against a broad range of major rice insect pests, including Coleoptera, Hemiptera, Lepidoptera, and Orthoptera, through nursery-box application. With a novel structural backbone and mode of action, this insecticide is classified by the Insecticide Resistance Action Committee as the sole member of novel code 37, vesicular acetylcholine transporter inhibitor. A substantial number of field studies in rice paddy fields have demonstrated that oxazosulfyl, registered in Japan in April 2021 as ALLES® granules, is highly effective against populations that have developed reduced sensitivity or resistance to existing insecticides. Given these favorable properties, oxazosulfyl is expected to contribute to the management of insecticide resistance, the reduction of agricultural chemical use, labor savings, and sustainable agriculture as a next-generation insecticide.

Keywords: broad spectrum; first-in-class; nursery box application; oxazosulfyl; resistance-breaker; sulfyl.

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Figures

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Fig. 1. Chemical structure of oxazosulfyl.
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Fig. 2. Optimization in the “sulfyl” chemical class, from the lead compound toward oxazosulfyl.
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Fig. 3. Baseline insecticidal activity of oxazosulfyl against field-collected planthoppers that show resistance to imidacloprid and/or fipronil comparison with that against respective susceptible strains. Numbers in the center of each graph indicate the resistance ratio of each compound in each planthopper species, which was calculated by dividing the LC50 values against the field population by that against the susceptible strain. Field populations were collected in rice fields in Satsumasendai, Kagoshima Prefecture in 2018, whereas laboratory strains, kept in Agro & Life Solutions Research Laboratory, Sumitomo Chemical Co., Ltd. in Takarazuka, Hyogo Prefecture, were used as susceptible strains.
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Fig. 4. Translocation of 14C oxazosulfyl in rice plants via soil drench application 3 days after the application (A) and mortality of Nilaparvata lugens nymphs released 3 days after soil application of oxazosulfyl (B). The same insect strains and populations used in Fig. 3 were used. *DAR, days after the release of the insects.
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Fig. 5. Damage by brown planthopper, Nilaparvata lugens, in the field study conducted in Kasai Agricultural Research Center, Agro & Life Solutions Research Laboratory, Sumitomo Chemical Co., Ltd. located in Kasai City, Hyogo Prefecture. Photo of the rice field 35 days after transplanting (A), in which the white arrows indicate the location where N. lugens has been released three times (35, 48 and 62 days after transplanting). Photos of the rice field 124 days after transplanting, from a bird’s eye view (B) and top view (C) taken by drone camera, in which untreated control is placed on the left side and oxazosulfyl on the right.
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Fig. 6. Field efficacy results against Nilaparvata lugens conducted in Kagoshima Prefecture in 2018. *DAP, days after the transplant.
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Fig. 7. ALLES® granule, contains 2.0% (w/w) oxazosulfyl.
See this image and copyright information in PMC

References

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