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Case Reports
. 2025 Sep 3:58:100957.
doi: 10.1016/j.ijmmb.2025.100957. Online ahead of print.

Microbiological and Clinical Epidemiology of Lomentospora prolificans infections

Lydia Jennifer Sumanth  1 , Rajiv Karthik  2 , Anuradha Chandramohan  3 , Aparna Irodi  4 , Rani D Sahni  5 , Joy Sarojini Michael  6
Affiliations
Case Reports

Microbiological and Clinical Epidemiology of Lomentospora prolificans infections

Lydia Jennifer Sumanth et al. Indian J Med Microbiol. .

Abstract

Lomentospora prolificans (formerly Scedosporium prolificans) is an emerging fungal pathogen, affecting both immunocompromised and immunocompetent individuals. Treatment is difficult due to intrinsic resistance against multiple anti-fungal agents. We describe five patients with L. prolificans infections attending a tertiary care center in South India. Out of the 5 patients, 4 patients presented with deep seated infection, and 1 with disseminated disease. Risk factors included uncontrolled diabetes mellitus, advanced HIV infection, T cell lymphoblastic leukemia, carcinoma breast, and immunosuppressant therapy. L. prolificans as an important causative agent of deep seated and disseminated mycoses among immunocompromised patients.

Keywords: Lomentospora prolificans; Scedosporium prolificans.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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