Insights Into Kaposi Sarcoma-Associated Herpesvirus-Specific Humoral Responses
- PMID: 40916576
- DOI: 10.1002/jmv.70597
Insights Into Kaposi Sarcoma-Associated Herpesvirus-Specific Humoral Responses
Abstract
Kaposi sarcoma (KS) remains a global health concern. In sub-Saharan Africa, where there is a high burden of HIV-1 infection, there is also a high prevalence of infection by the etiologic agent of KS, the KS-associated herpesvirus (KSHV). Despite the successes of antiretroviral treatment (ART), the burden of KS and other KSHV-associated malignancies among people living with HIV under ART remained high, stressing the need for a greater understanding of the immune response against KSHV infection. Here, we review the current information on KSHV-specific humoral response in infected individuals in detail. We discuss the significance of anti-KSHV responses, mechanisms used by KSHV to subvert and modulate humoral immunity, and implications for pathogenesis and therapy. We highlight cutting-edge serological assays and bioinformatics tools that aid the development of effective vaccines against KSHV, underscoring the complexity of the humoral response and its critical role within the context of infection and vaccine design.
Keywords: KSHV; humoral immunity; immunoinformatics; serology; vaccine development.
© 2025 Wiley Periodicals LLC.
References
-
- G. Sternbach and J. Varon, “Moritz Kaposi: Idiopathic Pigmented Sarcoma of the Skin,” Journal of Emergency Medicine 13, no. 5 (1995): 671–674.
-
- E. Cesarman, B. Damania, S. E. Krown, J. Martin, M. Bower, and D. Whitby, “Kaposi Sarcoma,” Nature Reviews Disease Primers 5, no. 1 (2019): 9.
-
- Y. Chang, E. Cesarman, M. S. Pessin, et al., “Identification of Herpesvirus‐Like DNA Sequences in AIDS‐associated Kaposi's Sarcoma,” Science 266, no. 5192 (1994): 1865–1869.
-
- E. Cesarman, Y. Chang, P. S. Moore, J. W. Said, and D. M. Knowles, “Kaposi's Sarcoma‐Associated Herpesvirus‐Like DNA Sequences in AIDS‐Related Body‐Cavity‐Based Lymphomas,” New England Journal of Medicine 332, no. 18 (1995): 1186–1191.
-
- M. Hayashi, K. Aoshiba, M. Shimada, Y. Izawa, S. Yasui, and A. Nagai, “Kaposi's Sarcoma‐Associated Herpesvirus Infection in the Lung in Multicentric Castleman's Disease,” Internal Medicine 38, no. 3 (1999): 279–282.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical