Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep;24(9):e70439.
doi: 10.1111/jocd.70439.

Clinical Perspectives on the Safety Profile of Poly-L-Lactic Acid (Juläine): Results From a National Survey

Affiliations

Clinical Perspectives on the Safety Profile of Poly-L-Lactic Acid (Juläine): Results From a National Survey

Maribel Serrano-Coronado et al. J Cosmet Dermatol. 2025 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Maribel Serrano‐Coronado and Dr. Victoria Páez Ruiz received research grants to cover the costs of medical writing services and publication fees, honoraria for lectures, and travel support to attend educational meetings from Nordberg Medical. Paula Catena Rallo, Francisca Rubio Toral, Cristina Chantada Tirado and Adriana Ribé Subirà has no financial interests to declare.

Figures

FIGURE 1
FIGURE 1
Adverse events (AEs) perceived as “rare” or “never observed” by ≥ 90% of the respondents. The percentages represent the proportion of respondents who classified the adverse event as “rare” or “never observed.” *Both early and late onset (≤ 3 months) and late (> 3 months). **Cramps in the injection area.

References

    1. Christen M. O., “Collagen Stimulators in Body Applications: A Review Focused on Poly‐L‐Lactic Acid (PLLA),” Clinical, Cosmetic and Investigational Dermatology 15 (2022): 997–1019, 10.2147/CCID.S359813. - DOI - PMC - PubMed
    1. Signori R., Barbosa A. P., Cezar‐Dos‐Santos F., et al., “Efficacy and Safety of Poly‐l‐Lactic Acid in Facial Aesthetics: A Systematic Review,” Polymers 16, no. 18 (2024): 2564, 10.3390/polym16182564. - DOI - PMC - PubMed
    1. Flores‐Jiménez I., Martínez‐Carpio P. A., and Alcolea‐López J. M., “Eficacia y Seguridad de Los Tratamientos Faciales Con Ácido Poliláctico,” accessed January 21, 2025, Revisión sistemática, https://www.seme.org/site/docs/revistaweb/Revista‐SEME‐67_2‐Flores‐2021.pdf.
    1. Xu Q., Sun X., Yang W., Bai Y., and Tan X., “Comprehensive Systematic Review of Poly‐L‐Lactic Acid in Facial Clinical Application,” Aesthetic Plastic Surgery 48, no. 23 (2024): 5115–5135, 10.1007/s00266-024-04098-8. - DOI - PubMed
    1. Magacho‐Vieira F. N. and Ducati E. P. J., “Clinical Management of Poly‐D,L‐Lactic Acid Nodules: A Guideline With Diagnostic and Treatment Flowchart,” Journal of Cosmetic Dermatology 24, no. 4 (2025): e70158, 10.1111/jocd.70158. - DOI - PMC - PubMed

Grants and funding

LinkOut - more resources