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. 2025 Aug 22:16:1617157.
doi: 10.3389/fimmu.2025.1617157. eCollection 2025.

Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review

Mateusz Matwiejuk  1 , Agnieszka Mikłosz  2 , Hanna Myśliwiec  1 , Adrian Chabowski  2 , Iwona Flisiak  1
Affiliations

Adipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review

Mateusz Matwiejuk et al. Front Immunol. .

Abstract

Adipose-derived mesenchymal stem cells (ADMSCs) offer a multifaceted approach to treating immune-mediated skin diseases by modulating the immune system and promoting tissue regeneration. Specifically, their ability to differentiate into multiple cell types such as keratinocytes and fibroblasts, modulate immune responses, and release growth factors and cytokines underscores their potential in treating a wide range of immune-related skin conditions. ADMSCs significantly reduced various aspects of psoriasis, including scaling, thickness, and erythema. Moreover, cell-free therapy has even better therapeutic potential. It has been shown that ADMSC-derived exosomes can effectively alleviate pathological symptoms of atopic dermatitis, including clinical score, serum IgE levels, eosinophil amount, and infiltration of immune cells in skin lesions. This systematic review summarizes the most relevant preclinical and clinical studies on the therapeutic use of ADMSCs and their small extracellular vesicles in the treatment of common skin diseases like psoriasis, atopic dermatitis, localized scleroderma and acne vulgaris.

Keywords: ADMSCs; acne vulgaris; atopic dermatitis; exosomes; localized scleroderma; psoriasis; skin diseases; small extracellular vesicles.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The potential mechanism of ADMSCs action in the treatment of inflammatory skin diseases (e.g., atopic dermatitis, psoriasis). ADMSCs, adipose-derived mesenchymal stem cells; ANG1, angiopoietin-1; CCL2, chemokine (C-C motif) ligand 2; CCL3, chemokine (C-C motif) ligand 3; CCL4, chemokine (C-C motif) ligand 4; CCL5, chemokine (C-C motif) ligand 5; CCL6, chemokine (C-C motif) ligand 6; CX3CL1, chemokine (C-X3-C motif) ligand 1; CXCL5, chemokine (C-X-C motif) ligand 5; FGF, fibroblast growth factor; IDO, indoleamine 2,3-dioxygenase; IGF-1, insulin-like growth factor 1; IL-10, interleukin 10; IL-6, interleukin 6; MCP-1, monocyte chemoattractant protein 1; NK, natural killer cells; PGE2, prostaglandin 2; TGF-β, tumor growth factor β; VEGF, vascular endothelial growth factor.
Figure 2
Figure 2
The search process.
See this image and copyright information in PMC

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