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. 2025 Jul 3;34(14):3225-3236.
doi: 10.1007/s10068-025-01933-9. eCollection 2025 Oct.

Development of transfersomal nanocarriers loaded with Javanese turmeric essential oils and evaluation of their biological activity

Lolyta Fitri Mustati  1 , Annisa Hana Mufidah  1 , Harris Antonius  1 , Yuli Widiyastuti  1 , Eldiza Puji Rahmi  2 , Yuandani  3 , Tri Yuliani  1 , Abdi Wira Septama  1
Affiliations

Development of transfersomal nanocarriers loaded with Javanese turmeric essential oils and evaluation of their biological activity

Lolyta Fitri Mustati et al. Food Sci Biotechnol. .

Abstract

Curcuma xanthorrhiza essential oils (CXEO) are widely used in many different sectors. Although CXEO's intriguing properties, its poor solubility and volatility have restricted its use. Thus, the study aimed to fabricate and characterize stable CXEO transferosome. The antibacterial, antioxidant and anti-inflammatory activities of this vesicle are determined. The optimized transferosomes entrapped 94.55 ± 2.78% of CXEO with particle size of 126.4 ± 2.4 nm, polydispersity index of 0.78 ± 0.01, and zeta potential value of -30.7 ± 0.2. CXEO-transferosome exhibited strong antibacterial activity against Staphylococcus epidermidis and Propionibacterium acnes with MIC values of 15.6 and 7.8 μg/mL, respectively. CXEO-transferosomes showed activity against DPPH and ABTS radicals with IC50 values of 258.50 ± 0.20 and 79.79 ± 0.04 μg/mL, respectively. Transferosome also possessed anti-inflammatory activity (21.82 ± 0.50%). The finding indicated that CXEO-transferosome enable to improve the biological activities of free CXEO and this product can be extended to relevant applications.

Keywords: Anti-inflammatory; Antibacterial; Antioxidant; Curcuma xantorrhizha; Essential oil; Nanocarrier; Transferosome.

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Conflict of interest statement

Competing interestsThe authors declare no competing interests.

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