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. 2025 Aug 7;17(8):e89563.
doi: 10.7759/cureus.89563. eCollection 2025 Aug.

Managing Laryngeal Carcinoma in the United Arab Emirates: An Experience From the Tertiary Care Center

Affiliations

Managing Laryngeal Carcinoma in the United Arab Emirates: An Experience From the Tertiary Care Center

Reem Aldhaheri et al. Cureus. .

Abstract

Background Laryngeal cancer is a common head and neck malignancy. The treatment modalities differ depending on the clinical staging and location of the tumor, hence affecting the survival outcomes. Objective This study aims to provide demographic information and survival outcomes in laryngeal cancer patients in the UAE, considering the clinical staging and treatment received. Methods A retrospective cohort study in laryngeal cancer patients at Tawam Hospital from 2016 to 2020. Descriptive analysis summarized the demographics and survival analysis using Kaplan-Meier curves, comparing outcomes between early and advanced stages, as well as treatment modality (surgical vs non-surgical). We also used the log-rank test to assess statistical significance. Results A total of 63 patients were included in the study. Patients with early-stage disease showed better survival in the surgical compared to the non-surgical primary treatment. On the contrary, patients with advanced-stage disease had better survival outcomes in the non-surgical treatment group than in the surgical group. Conclusion Compared to early-stage disease, the treatment modality does affect the survival outcomes in advanced stages. These results suggest a potential benefit favoring the non-surgical treatment modality, but further prospective studies with larger sample sizes are needed.

Keywords: chemoradiotherapy; laryngeal cancer; retrospective study; surgical treatment; survival analysis; treatment outcomes.

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Conflict of interest statement

Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Tawam Human Research Ethics Committee (T-HREC ) issued approval MF2058-2025-1274. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Laryngeal subunits involved, labeled with percentages
The figure demonstrates higher involvement of the glottic subunit.
Figure 2
Figure 2. Kaplan-Meier survival analysis between early vs advanced laryngeal cancer cases
Figure 3
Figure 3. Kaplan-Meier survival analysis between patients between surgical vs. non-surgical treatment
Figure 4
Figure 4. Both early-stage groups (surgical and nonsurgical) show excellent survival, while the advanced + surgical group shows the lowest survival

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