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. 1985 Dec;20(6):707-9.
doi: 10.1111/j.1365-2125.1985.tb05135.x.

Amiodarone reduces plasma warfarin clearance in man

A H Watt, M R Stephens, D C Buss, P A Routledge

Amiodarone reduces plasma warfarin clearance in man

A H Watt et al. Br J Clin Pharmacol. 1985 Dec.

Abstract

Amiodarone is an effective antiarrhythmic agent whose use is associated with several drug interactions one of which is potentiation of the action of warfarin. The mechanism of this interaction has hitherto been unclear. We examined possible mechanisms in eight patients. Total plasma warfarin clearance was found to be reduced by amiodarone. No change was detected in the binding of warfarin to plasma proteins. No relationship was found between plasma amiodarone concentrations and the change in warfarin clearance.

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