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Review
. 2025 Aug 29;42(4):2025-vol4.
doi: 10.69097/42-04-2025-05.

[SGLT2i: Exploring Multiple Pathways in Cardiorenal Protection. Insights Into Nutrient Deprivation]

[Article in Italian]
Fabio Mazza  1 , Francesca Apponi  2 , Angela Cicciarelli  1 , Filomena Rubino  1 , Ernesto Anselmo Cioffi  1 , Roberto Simonelli  3
Affiliations
Review

[SGLT2i: Exploring Multiple Pathways in Cardiorenal Protection. Insights Into Nutrient Deprivation]

[Article in Italian]
Fabio Mazza et al. G Ital Nefrol. .

Abstract

SGLT-2 inhibitors are a relatively new class of antidiabetic drugs. They activate a transcriptional response similar to calorie restriction characterized by the up-regulation of sensors involved in nutrient deprivation, such as SIRT1 and AMPK, and the down-regulation of mTOR, a molecule involved in nutritional excess signaling. The purpose of this review is to illustrate the main pathways of nutrient deprivation: a complex mechanistic framework partly responsible for the cardio-renal benefits that makes these drugs unique.

Keywords: AMPK; ROS; SGLT2i; autophagy; mTORC1; mitophagy.

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