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Comparative Study
. 1985;8(3-4):285-95.
doi: 10.1016/0147-9571(85)90007-4.

Freeze-dried vaccine against Rinderpest: stability and activity study

B Languet, P Precausta, M Mackowiak, P Dubourget, G Reynaud, C Duret
Comparative Study

Freeze-dried vaccine against Rinderpest: stability and activity study

B Languet et al. Comp Immunol Microbiol Infect Dis. 1985.

Abstract

A freeze-dried vaccine against Rinderpest was prepared from modified virus multiplied in calf kidney cell culture. Characteristics of the vaccine are as follows: high titre after freeze-drying (10(4) CCID50/dose), well-adapted freeze-drying stabilizer which ensures maintenance of the infective titre of the vaccinal virus, even under severe conditions (3.5 days at +45 degrees C), use of an appropriate solvent: magnesium sulphate molar solution or more simply physiological saline (for stability after reconstitution even at high temperatures--up to 4 h at +45 degrees C). The activity of the vaccine, tested in cattle by antibody titration and resistance to specific challenge perfectly satisfies requirements set by the WHO and OIE.

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